Guided Conditional Diffusion Classifier (ConDiff) for Enhanced Prediction of Infection in Diabetic Foot Ulcers.

To accurately detect infections in Diabetic Foot Ulcers (DFUs) using photographs taken at the Point of Care (POC). Achieving high performance is critical for preventing complications and amputations, as well as minimizing unnecessary emergency department visits and referrals. This paper proposes the Guided Conditional Diffusion Classifier (ConDiff).

Latent Dynamical Model to Characterize Brain Network-Level Rhythmic Dynamics.

Characterizing network-level rhythmic dynamics over multiple spatio-temporal scales can significantly advance our understanding of brain cognitive function and information processing. In this research, we propose a new switching state space model called latent dynamical coherence model or briefly LDCM. In the LDCM, we develop model inference and parameter estimation solutions that facilitate studying network-level rhythmic dynamics at scales.

Synchrony-Division Neural Multiplexing: An Encoding Model.

Cortical neurons receive mixed information from the collective spiking activities of primary sensory neurons in response to a sensory stimulus. A recent study demonstrated an abrupt increase or decrease in stimulus intensity and the stimulus intensity itself can be respectively represented by the synchronous and asynchronous spikes of S1 neurons in rats. This evidence capitalized on the ability of an ensemble of homogeneous neurons to multiplex, a coding strategy that was referred to as synchrony-division multiplexing (SDM).

Application of Global Coherence Measure to Characterize Coordinated Neural Activity during Frontal and Temporal Lobe Epilepsy.

Time- and frequency-domain studies of EEG signals are most commonly employed to study the electrical activities of the brain in order to diagnose potential neurological disorders. In this work, we applied the global coherence approach to help estimating the neural synchrony across multiple nodes in the brain, prior and during a seizure. The ratio of the largest eigenvalue to the sum of the eigenvalues of the cross spectral matrix at a certain frequency and time allowed detecting a strong coordinated neural activity in alpha sub-band for the frontal lobe epilepsy.

State-Space Global Coherence to Estimate the Spatio-Temporal Dynamics of the Coordinated Brain Activity.

Characterizing coordinated brain dynamics present in high-density neural recordings is critical for understanding the neurophysiology of healthy and pathological brain states and to develop principled strategies for therapeutic interventions. In this research, we propose a new modeling framework called State Space Global Coherence (SSGC), which allows us to estimate neural synchrony across distributed brain activity with fine temporal resolution. In this modeling framework, the cross-spectral matrix of neural activity at a specific frequency is defined as a function of a dynamical state variable representing a measure of Global Coherence (GC); we then combine filter-smoother and Expectation-Maximization (EM) algorithms to estimate GC and the model parameters.