Does Charge Balancing Ensure the Safety of the Electrical Stimulation and Is It Power Efficientƒ.

Safety issues are the most important concern in electrical stimulation. Equating the charge in the anodic and cathodic phases, namely charge balancing or charge equalizing, is a well-known method to avoid tissue damage and/or electrode corrosion. The electrode-tissue interface is not ideal in practice and with a charge-balanced waveform, the electrode voltage becomes more positive compared to the pre-pulse value and corrosion happens.

A Review of Microelectronic Systems and Circuit Techniques for Electrical Neural Recording Aimed at Closed-Loop Epilepsy Control.

Closed-loop implantable electronics offer a new trend in therapeutic systems aimed at controlling some neurological diseases such as epilepsy. Seizures are detected and electrical stimulation applied to the brain or groups of nerves. To this aim, the signal recording chain must be very carefully designed so as to operate in low-power and low-latency, while enhancing the probability of correct event detection.