Bipolar fractional radiofrequency treatment induces neoelastogenesis and neocollagenesis.

Background: We recently introduced Renesis, a novel minimally invasive radiofrequency (RF) device, for the treatment of human skin. The wound healing response post-fractional RF (FRF) treatment was examined in human subjects.

Study Design: The FRF system delivered RF energy directly within the dermis via 5 micro-needle electrode pairs.

Effect of increased pigmentation on the antifibrotic response of human skin to UV-A1 phototherapy.

Objective: To investigate the efficacy, potential limitations, and biological mechanisms of UV-A1 phototherapy for skin sclerosis due to collagen deposition disorders.

Design: Before-and-after trial of UV-A1 irradiation of sclerotic skin; in vivo biochemical analyses after UV-A1 irradiation of normal skin.

Setting: Academic referral center.

Improvement of naturally aged skin with vitamin A (retinol).

Objective: To evaluate the effectiveness of topical retinol (vitamin A) in improving the clinical signs of naturally aged skin.

Design: Randomized, double-blind, vehicle-controlled, left and right arm comparison study.

Setting: Academic referral center.