Publications by authors named "Reza Hadi"

Article Synopsis
  • Blood-based small molecule metabolites can provide valuable insights into health and disease risk, especially in understanding heart failure (HF) through metabolite profiling in individuals who initially do not have HF.
  • The study used network analysis to reveal how metabolites interact and their roles in influencing HF risk, while controlling for confounding factors among metabolites.
  • Key findings indicate that certain metabolites, like glycine and asparagine, are linked to both dietary intake and genetic factors, highlighting their importance in predicting HF incidence and understanding complex health conditions.
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Background And Study Aims: Diet is an important underlying factor in ulcerative colitis (UC) disease. The present study aimed to investigate the effect of a gluten-free diet (GFD) on disease severity, quality of life, and inflammatory markers in patients with UC.

Patients And Methods: In this triple-blind randomized placebo-controlled clinical trial, we evaluated the effect of a GFD on the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fecal calprotectin, disease severity, and quality of life in patients with mild to moderate UC.

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Article Synopsis
  • Monoclonal antibody therapies have improved cancer survival rates, but individual responses vary, necessitating the identification of cancer subtypes and biomarkers for effective treatment.* -
  • This study focused on colorectal cancer, combining genotype and RNA-seq data to find biomarkers linked to overall survival for patients treated with cetuximab or bevacizumab.* -
  • Notably, a gene found to be overexpressed in certain subtypes was linked to shorter survival for cetuximab patients, suggesting that specific subtypes may respond better to certain treatments.*
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Article Synopsis
  • This study focused on identifying gene interconnectivity, specifically in metastatic colorectal cancer (CRC), to improve patient treatment by linking gene networks to overall survival (OS) outcomes.
  • Researchers analyzed data from 1,165 patients in a clinical trial comparing treatments with cetuximab and bevacizumab, discovering gene signatures that predict patient survival based on specific treatments.
  • The identified gene signatures not only showed downregulation in CRC tumors compared to normal tissue but also highlighted proteins that interact functionally, indicating their potential as novel biomarkers for personalized cancer treatment.
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Background: Gastric cancer (GC) is one of the most common Cancers in the world and Helicobacter pylori (HP) infection is considered a causative factor. The aim of this study was to determine the characteristics and the associated factors of (GC) in a small cohort.

Methods: Overall, 54 patients with diagnosed gastric cancer were followed-up at the Department of Gastroenterology & Hepatology at Baqiyatallah University of Medical Sciences.

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Context: Occult HCV infection (OCI) is defined as the presence of HCV-RNA in hepatocytes and the absence of HCV in the serum according to usual tests. We aimed to define OCI and provide information about the currently available diagnostic methods. Then we focus on specific groups that are at high risk of OCI and finally investigate immune responses to OCI and the available treatment approaches.

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We examined the effect of potential interfering factors that play major roles in the outcome of our patients with stomach cancer. 100 consecutive patients diagnosed with gastric cancers were prospectively observed, treated and followed from November 2009 to January. Absence of Helicobacter pylori infection (P=0.

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Objective: To explore demographic and metabolic factors associated with increased alanine aminotransferase (ALT) activity in non-diabetic non-alcoholic fatty liver disease (NAFLD) patients.

Methods: Overall 372 patients who consecutively attended to Gastroenterology Clinic of Baqiyatallah University of Medical Sciences, Tehran, Iran awere diagnosed as NAFLD entered into analysis. Exclusion criteria were having diabetes mellitus and fasting blood glucose over 126 mg/dL, active hepatitis B virus infection, having hepatitis C virus positive serology, and to be under corticosteroid therapy.

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Epilepsy is an important disease with a cumulative incidence of 3% all over the life and more than half of them are started from childhood. In this study we surveyed magnetic resonance imaging (MRI) findings in epileptic children and its relation with clinical and demographic findings in order to find better diagnostic and treatment modalities for these children in the future. In this cross sectional study, we investigated consecutively all 1 to 15-year-old epileptic children who referred to the pediatric neurology outpatient clinic from 2004 to 2010.

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