Evaluation of Th17 pathway in the diagnosis of autosomal dominant polycystic kidney disease.

Introduction: Current assessment tools of autosomal dominant polycystic kidney disease (ADPKD) diagnosis are challenging. This study evaluated the possible application of assessment of interleukin (IL)-17-related cytokines and the circulatory T helper 17 cells in the diagnosis of ADPKD.

Materials And Methods: Enrolling 54 ADPKD patients and 54 healthy individuals, we measured serum and urine levels of IL-6, IL-17, IL-23, and transforming growth factor-β and the peripheral blood frequency of T helper 17 cells through flowcytometry.