Publications by authors named "Reydson Alcides de Lima-Souza"
Prognostic implications across histological subtypes of head and neck squamous cell carcinoma: An update.
J Stomatol Oral Maxillofac Surg
November 2024
Article Synopsis
- * This review examines existing research on the prognostic implications of HNSCC’s histopathologic subtypes, noting a lack of studies focusing specifically on treatment outcomes for each subtype.
- * The review highlights that some subtypes, like verrucous and cuniculatum, have better prognoses compared to others like basaloid and spindle cell, and it emphasizes the need for more molecular research to develop targeted therapies and improve prognostic assessments.
Article Synopsis
- - Hybrid carcinomas (HC) in salivary glands are rare tumors that involve the combination of two or more malignant neoplasms, primarily occurring in the parotid gland and often in male patients.
- - The study reviewed 18 articles with data on 34 patients, finding that adenoid cystic carcinoma and epithelial-myoepithelial carcinoma were the most common types, and surgical excision followed by radiotherapy was the typical treatment approach.
- - There’s a need for further research to understand whether HC are distinct from individual cancer types, as the most aggressive tumor component should determine treatment strategies to improve patient outcomes.
Article Synopsis
- Carcinoma ex pleomorphic adenoma (CXPA) is a type of aggressive tumor connected to pleomorphic adenomas, and its development is linked to various genetic and epigenetic changes.
- A study reviewed 84 cases of CXPA, uncovering several types of carcinoma, with notable findings from next-generation sequencing and fluorescence in situ hybridization revealing genetic fusions and alterations.
- The research highlighted that CXPA with myoepithelial characteristics often showed chromosomal fusion events, while those with epithelial traits had more pathogenic mutations and gene amplifications.
Article Synopsis
- - A 56-year-old woman was referred for treatment of a malignant salivary gland tumor that was growing rapidly and causing pain and breathing issues, with a previous biopsy showing compromised margins.
- - Physical exams and CT scans indicated an aggressive lesion in the left soft palate, measuring about 3 cm, that was invading nearby structures.
- - Following surgery, the tumor was diagnosed as secretory carcinoma, characterized by specific cellular patterns and behaviors, and the patient is being monitored for additional treatment options.
Article Synopsis
- * Of the 51 articles found, 18 met the criteria, revealing that solitary angiokeratomas mostly affect men in their 40s, with the tongue being the most common location for these lesions.
- * The lesions generally have a good prognosis and were mainly treated through surgical excision, and it's crucial for healthcare professionals to recognize these lesions in order to differentiate them from other pigmented oral conditions.
Article Synopsis
- The Eph/ephrin system plays a crucial role in various developmental processes and maintaining tissue health in adults, specifically affecting colorectal cancer (CRC) in areas like tumor development and metastasis.
- There is conflicting evidence about the role of Eph receptors in CRC, creating confusion about whether they act as oncogenes (cancer-promoting) or tumor suppressors.
- This review analyzes existing literature on the Eph/ephrin system in CRC, emphasizing uncertain roles and potential molecular targets for future cancer therapies.
Background: Salivary gland carcinomas (SGCs) are a rare group of malignant neoplasms of the head and neck region. MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been associated with the control biological process and oncogenic mechanism by the regulation of gene expression at the post-transcriptional level. Recent evidence has suggested that miRNA expression may play a role in the tumorigenesis and carcinogenesis process in SGCs.
View Article and Find Full Text PDFClinical and epidemiological profile of burning mouth syndrome patients following the International Headache Society classification: a systematic review and meta-analysis.
Oral Surg Oral Med Oral Pathol Oral Radiol
February 2024
Objective: This systematic review aimed to determine the clinical and epidemiologic profile of patients with burning mouth syndrome (BMS) following the current classification of the International Headache Society (IHS)-the International Classification of Headache Disorders (ICHD-3) and the International Classification of Orofacial Pain (ICOP).
Study Design: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and involved a comprehensive search on PubMed, Scopus, EMBASE, Web of Science, LILACS, and the gray literature.
Results: Of the 4,252 studies identified, 41 were included.
Reported physical examination methods for screening of oral cancer and oral potentially malignant disorders: a systematic review.
Oral Surg Oral Med Oral Pathol Oral Radiol
February 2024
Objective: This systematic review aimed to describe the method followed during physical examination and the anatomical structures of the head and neck assessed in screening for oral cancer and oral potentially malignant disorders (OPMDs).
Study Design: An extensive literature search was carried out using MEDLINE/PubMed, EMBASE, Scopus, LILACS, Web of Science, Cochrane databases, and gray literature. The risk of bias was available in all papers included.
Colony-stimulating factors (CSFs) are key cytokines responsible for the production, maturation, and mobilization of the granulocytic and macrophage lineages from the bone marrow, which have been gaining attention for playing pro- and/or anti-tumorigenic roles in cancer. Head and neck cancers (HNCs) represent a group of heterogeneous neoplasms with high morbidity and mortality worldwide. Treatment for HNCs is still limited even with the advancements in cancer immunotherapy.
View Article and Find Full Text PDFIn this systematic review, we aimed to evaluate the clinicopathological profile of sclerosing polycystic adenoma (SPA). PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched to access cases of SPA in salivary glands. One hundred and thirty cases of SPA were found across 61 selected articles.
View Article and Find Full Text PDFHeterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights.
Front Oral Health
April 2023
Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%-60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA).
View Article and Find Full Text PDFObjectives: In this systematic review, we aimed to evaluate the clinicopathological and prognosis data of patients with salivary gland myoepithelial carcinoma.
Materials And Methods: MEDLINE/PubMed, Scopus, and Embase search was performed with the keywords "myoepithelial carcinoma" "malignant myoepithelioma," and "salivary glands." Primary salivary glands myoepithelial carcinoma that fulfilled the World Health Organization diagnostic criteria were included.
Article Synopsis
- - Villitis of unknown etiology (VUE) is an inflammatory condition marked by the presence of maternal CD8 +T cells in the placenta, with its causes still under discussion.
- - The disease likely stems from immune system dysregulation, where maternal T cells react to fetal antigens, prompting the onset of VUE.
- - This review draws parallels between VUE, graft vs host disease (GVHD), and allograft rejection to deepen understanding of VUE's mechanisms, potentially informing future treatment approaches.
The aim of this study was to evaluate the awareness of patients using bisphosphonates (BP) regarding their risks and benefits. Sixty-five patients using BP were included. Each participant completed a self-administered questionnaire consisting of 13 questions, including sociodemographic and general information on BP.
View Article and Find Full Text PDFSquamous cell carcinomas (SCC) are the most common malignant tumors that arise in the head and neck. Despite advances in the management of affected patients, the mortality burden of these tumors is increasing every year. The discovery of a vast genetic landscape has revealed new opportunities for therapeutic intervention of head and neck SCC (HNSCC).
View Article and Find Full Text PDFArticle Synopsis
- * The tumor analysis showed multiple tissues, including mature fat, hair follicles, sebaceous glands, and nerve structures, surrounded by skin-like cells, alongside various other cell types at the back of the tumor.
- * Although the tumor was primarily identified as a teratoma with elements from all three germ layers, the front had a unique structure that aligned with the characteristics of a hairy polyp.
Salivary gland carcinomas (SGC) are rare tumors of heterogeneous morphology and many histological subtypes. Like other tumors, the SGC mass consists of a varied population of malignant cells and a diverse array of immune cells, cancer-associated fibroblasts, cytokines, chemokines, extracellular matrix proteins, and metalloproteinases, collectively known as the tumor microenvironment (TME). This chaotic network serves as an important physical mediator of cancer cell growth.
View Article and Find Full Text PDFObjective: To integrate all the available data published in the English literature regarding the protein diagnostic and/or prognostic markers in salivary gland tumors identified by mass spectrometry (MS)-based discovery proteomics.
Design: An extensive search was carried out using MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases. Manual searching in Google Scholar and assessment of the reference list of the included articles also was performed.
Article Synopsis
- Salivary gland carcinomas (SGC) are aggressive cancers originating in salivary glands, presenting challenges in diagnosis and treatment due to their complexity and various subtypes.
- Recent research has shifted focus to the tumor microenvironment, especially immune and stromal cells, as a potential target for therapy, despite limited success with immunotherapy in SGC patients.
- The review discusses various experimental models of SGC, emphasizing the tumor microenvironment and exploring potential therapeutic applications for each model to enhance treatment responses in advanced stages of the disease.