Ann Clin Psychiatry
November 2010
J Clin Psychopharmacol
February 2010
Objective: To review the pharmacology, pharmacokinetics, clinical use, and potential adverse effects of lamotrigine in elderly patients with epilepsy.
Data Sources: English-language literature regarding humans was searched from January 1990 through January 2003 using PubMed and the terms "lamotrigine," "epilepsy," and "elderly."
Study Selection: Studies of epilepsy treatment with lamotrigine in elderly patients, review articles, pharmacokinetic and pharmacodynamic studies, and clinical studies/reports regarding adverse effects of lamotrigine were evaluated.
Study Objective: To assess patient tolerability and impact on institutional drug acquisition costs of converting patients from sustained-release bupropion to generic immediate-release bupropion.
Design: Retrospective medical record review.
Setting: Veterans Affairs medical center.