Publications by authors named "Rex Jeya Rajkumar Samdavid Thanapaul"

Senescent cells accumulate in aging tissues, impairing their ability to undergo repair and regeneration following injury. Previous research has demonstrated that targeting tissue senescence with senolytics can enhance tissue regeneration and repair by selectively eliminating SnCs in specific aged tissues. In this study, we focused on eliminating senescent skin cells in aged mice to assess the effects on subsequent wound healing.

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Article Synopsis
  • Senescent cells accumulate in aging tissues and hinder the body's repair mechanisms, but using senolytics like ABT-263 can help improve tissue regeneration.
  • In this study, applying ABT-263 to the skin of older mice reduced markers of senescence and led to faster wound healing by activating genes related to healing processes.
  • While ABT-263 effectively cleared out senescent skin cells and improved wound closure, it also caused a temporary inflammatory response, indicating a complex balance in its effects.
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species cause debilitating, life-threatening sinopulmonary diseases in immunocompromised patients and penetrating wounds in trauma victims. Common antifungal agents against mucormycosis have significant toxicity and are often ineffective. To evaluate treatments against mucormycosis, sporangiospores are typically used for in vitro assays and in pre-clinical animal models of pulmonary infections.

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Society and our healthcare system are facing unprecedented challenges due to the expansion of the older population. As plastic surgeons, we can improve care of our older patients through understanding the mechanisms of aging that inevitably impact their outcomes and well-being. One of the major hallmarks of aging, cellular senescence, has recently become the focus of vigorous research in academia and industry.

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Article Synopsis
  • Elevated cellular senescence can influence wound healing, but its exact impact—whether helpful or harmful—is still not fully understood.
  • A study using irradiated fibroblasts in young mice created an elevated senescence model, resulting in increased levels of senescent cells in the skin.
  • This heightened senescence significantly delayed wound healing, mimicking the healing responses seen in older mice, suggesting that targeting senescent cells could improve wound healing outcomes.
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Article Synopsis
  • Senescence is a cellular response to stress that stops cell division and leads to a specific pattern of secretions linked to aging and related diseases.
  • The transition to a senescent state involves complex factors, particularly the regulation of multiple genes through transcription.
  • Epigenetic changes, such as alterations in chromatin structure, DNA methylation, and histone modifications, are key in initiating and sustaining cellular senescence and its secretory features.
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Cellular senescence has been found to have beneficial roles in development, tissue regeneration, and wound healing. However, in aging senescence increases, and the ability to properly repair and heal wounds significantly declines across multiple tissues. This age-related accumulation of senescent cells may cause loss of tissue homeostasis leading to dysregulation of normal and timely wound healing processes.

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This is the first study to report the green synthesis of mediated silver nanoparticles (LTAgNPs). The optical and structural properties of the synthesised LTAgNPs were analysed using ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier transform infrared, dynamic light scattering and energy dispersive X-ray. LTAgNps were evaluated for their anti-bacterial and anti-fungal properties against 18 pathogens and exhibited significant inhibition against all the strains tested.

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This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third-degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had noteworthy contraction and quicker eschar removal in 10% w/w LT-treated groups followed by 5% w/w treated groups on comparing with the commonly prescribed ointment (Silverex containing 1% w/w Silver sulfadiazine).

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