Publications by authors named "Rex A Jennings"
Article Synopsis
- A new method for producing (S)-(+)-3-aminomethyl-5-methylhexanoic acid, also known as Pregabalin, is presented.
- The process involves a crucial step where a specific acid salt undergoes asymmetric hydrogenation using a rhodium catalyst, resulting in a high enantiomeric excess for the desired compound.
- A follow-up hydrogenation of the product's nitrile using a nickel catalyst yields Pregabalin with excellent yield and purity.
