Publications by authors named "Reva Hawkins"
The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences of excess free histones. Our accompanying study has shown that a histone modification that loosens the intrinsic structure of the nucleosome, phosphorylation of histone H3 on threonine 118 (H3 T118ph), exists on centromeres and chromosome arms during mitosis. Here, we show that H3 T118ph localizes to centrosomes in humans, flies, and worms during all stages of mitosis.
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- * This phosphorylation occurs at specific locations on chromosomes and is crucial for proper mitotic processes; mutations that mimic this phosphorylation cause significant mitotic defects in human cells.
- * Maintaining normal levels of H3 T118ph is essential for chromosome segregation during mitosis, as it facilitates the timely release of important structural proteins, cohesin and condensin I, ensuring accurate cell division.