Publications by authors named "Reuven Jhirad"
Article Synopsis
- The study examined toxicological deaths in Ontario between 2018 and 2021, focusing on changes due to the COVID-19 pandemic.
- Researchers used coroner's data to analyze postmortem examinations and categorized deaths by cause and manner, isolating toxicological cases for comparison.
- Findings revealed a significant increase (22%) in deaths, with a notable rise in drug-related deaths and a dominance of fentanyl; men, particularly those aged 30-39, were disproportionately affected.
Article Synopsis
- - The study aimed to identify factors related to maternal deaths around pregnancy by analyzing coroner's data in Ontario, Canada, from 2004 to 2020.
- - Researchers found three distinct groups of maternal deaths: those occurring in hospitals during or shortly after birth (52.7%), those from accidents or complications (26.3%), and postpartum suicides (21.0%).
- - Key causes of death included physical injury (22.0%), hemorrhage (16.8%), and overdose (13.3%), suggesting these findings could help improve clinical practices and policies to reduce maternal mortality.
There has been a worldwide substantial increase in accidental opioid-overdose deaths. The aim of this review, along with preliminary results from our pilot study, is to highlight the use of pharmacogenetics as a tool to predict causes of accidental opioid-overdose death. For this review, a systematic literature search of PubMed between the time period of January 2000 to March 2023 was carried out.
View Article and Find Full Text PDFReviewing pharmacogenetics to advance precision medicine for opioids.
Biomed Pharmacother
October 2021
Background: Adequate opioid prescribing is critical for therapeutic success of pain management. Despite the widespread use of opioids, optimized opioid therapy remains unresolved with risk of accidental lethal overdosing. With the emergence of accumulating evidence linking genetic variation to opioid response, pharmacogenetic based treatment recommendations have been proposed.
View Article and Find Full Text PDFBackground: There is an increased risk of death due to drug toxicity after release from incarceration. The purpose of this study was to describe the timing, rate and circumstances of drug toxicity deaths following release from incarceration. This information can be used to help design potential preventive interventions.
View Article and Find Full Text PDFBackground: Spirometry is recommended for the diagnosis of asthma and chronic obstructive pulmonary disease (COPD) in international guidelines and may be useful for distinguishing asthma from COPD. Numerous spirometry interpretation algorithms (SIAs) are described in the literature, but no studies highlight how different SIAs may influence the interpretation of the same spirometric data.
Aims: We examined how two different SIAs may influence decision making among primary-care physicians.