Fructosamine. A new parameter for diagnosis and metabolic control in diabetic dogs and cats.

Fructosamines are glycated serum proteins that, depending on their life span, reflect glycemic control over the previous 2 to 3 weeks. The nitroblue tetrazolium reduction method adapted to auto analysis appeared to be a practical means to assay fructosamine quickly, economically, and accurately. The upper limit of the reference range is 374 mumol/L in dogs (95% percentile) and 340 mumol/L in cats (95% percentile).

[Endothelin-1 and endothelin-3 in the plasma of dogs].

The endothelins represent a family of peptides with potent vasoconstrictory effects indicating a role in the regulation of vascular tone. An involvement of endothelins in the pathogenesis as well as pathophysiology of vascular diseases has been proposed. Therefore, the aim of the presented study was to develop the methodology to measure and characterize endothelin-1 (ET-1) and endothelin-3 (ET-3) in the plasma of dogs.

Atrial natriuretic peptide concentration in dogs with congestive heart failure, chronic renal failure, and hyperadrenocorticism.

The function of atrial natriuretic peptide (ANP) is claimed to be control of salt and water homeostasis, and thus, the hormone may be involved in the pathogenesis of certain diseases with impaired volume regulation. We, therefore, studied plasma ANP concentration in dogs with chronic renal failure, congestive heart failure, and hyperadrenocorticism. Dogs with chronic renal failure had twofold higher plasma ANP concentration (16.

[Indocyanine green test in the dog].

The ICG test is recommended as a replacement for the nowadays rarely performed BSP test. ICG has less side effects, and it has a greater range of use. Extrahepatic influences are of little importance.

[Pathological changes of the endocrine pancreas in dogs and cats in comparison with clinical data].

In a retrospective study concerning the functional morphology of the endocrine pancreas the files of the Institute for Veterinary Pathology, University of Munich, of the last 12 years were reviewed. Cases of diabetes mellitus as well as developmental disorders and tumors of the endocrine pancreas were examined by routine histological and immunohistological methods. Cases are discussed together with clinical data and the relevant literature.

[Diagnostic possibilities of ANP blood measurements in dogs].

Atrial natriuretic peptide has been considered to be a major regulator in the body's water and salt homeostasis. Antagonizing those mechanisms leading to volume retention and overload (renin, angiotensin, aldosterone), ANP has been suggested to play a critical role in the pathology of certain diseases like renal failure, congestive heart failure or hypertension. In this regard, we measured ANP plasma concentration in normal healthy dogs and dogs with renal failure, congestive heart failure and Cushing syndrome.

Enzyme activities of urinary alanine aminopeptidase (AAP) and N-acetyl-beta-D-glucosaminidase (NAG) in healthy dogs.

The activity of the urinary enzymes alanine aminopeptidase (AAP; EC 3.4.11.

[Laboratory parameters for the control of the course of therapy of canine Cushing's syndrome].

We compared the results of the ACTH stimulation tests with measurements of alkaline phosphatase and serum cholesterol during Lysodren therapy in 23 dogs with pituitary-dependent hyperadrenocorticism. The ACTH stimulation test proved to be a very sensitive parameter, by which the extent of Lysodren under- or overdosage could be reliably estimated. On the other hand, regulation of the individual Lysodren requirement was not possible by measuring AP and serum cholesterol only.

Canine hyperadrenocorticism due to adrenocortical neoplasia. Pretreatment evaluation of 41 dogs.

This retrospective study identifies parameters that might separate dogs with hyperadrenocorticism caused by adrenocortical tumors from dogs with pituitary-dependent hyperadrenocorticism. Further, an attempt was made to identify factors that could separate dogs with adrenocortical adenomas from dogs with carcinomas. The records of 41 dogs with hyperadrenocorticism caused by adrenocortical neoplasia were reviewed.

[The diagnostic significance of the protein-creatinine ratio in urine for the differentiation of feline nephropathies].

The normal U-P/C-range in cats was established with urine samples of 19 cats. The upper limiting value was fixed at 0.33 (mean +/- 2s).

[Diabetic neuropathy in dogs and cats--a bioptic electron microscopic study].

Electron microscopic examination of peripheral nerves within dermal corium based upon skin biopsies (punch diameter = 6 mm) of chronic diabetic dogs and cats in comparison with normal controls revealed that more than 90% of the diabetic animals (31/34 dogs, 9/10 cats) had developed characteristic neuropathies. The main features were of axonal atrophy of myelinated and unmyelinated fibers, demyelination and - to a lesser degree - intraaxonal accumulation of glycogen (about 25%). In contrast with human diabetic polyneuropathy vascular basement membranes were throughout of normal appearance.

[Tumors of the exocrine pancreas in the cat].

Five cases of carcinoma and one case of lymphosarcoma of the pancreas in cats are reported. Duration of clinical signs ranged between three days and ten weeks, the mean age was 10.2 years.

[Imported leishmaniasis of dogs: clinical aspects, diagnosis and therapy with Na stibogluconate (Pentostam)].

Between May 1982 and September 1986 13 dogs with leishmaniosis received inpatient treatment with Pentostam at the I. Medical Department of the Veterinary Faculty, University of Munich. Predominant clinical signs of all animals were alterations of the skin and hair coat and additionally they showed a reduced general condition (4 dogs), loss of weight (3 dogs), diarrhea (5 dogs) and pain during movements.

[Photometric determination of chymotrypsin in feces of the dog. A new method in the diagnosis of chronic exocrine pancreatic insufficiency].

The advantages of the photometrical analysis of chymotrypsin in stool of dogs are: the short duration of procedure, the small amount of stool necessary and the simplified manner of measurement at 405 nm. The test was performed in healthy as well as in chronically pancreatic insufficient dogs and those with other origins of diarrhea. The normal value for healthy dogs was more than 1 U chymotrypsin/g stool.