The Impact of Body Composition on Mortality and Hospital Length of Stay after Endovascular and Open Aortic Aneurysm Repair: A Retrospective Cohort Study.

Sarcopenia is an indicator of preoperative frailty and a patient-specific risk factor for poor prognosis in elderly surgical patients. Some studies have explored the prognostic significance of body composition parameters in relation to perioperative mortality after aortic repair and to mid- and long-term survival following endovascular aneurysm repair (EVAR). This study aimed to comprehensively investigate the effects of various body composition parameters, including but not limited to sarcopenia, on short- and long-term mortality as well as the length of hospital stay in two large cohorts of patients undergoing open surgical aortic repair (OSR) or EVAR.

Upgrading Monocytes Therapy for Critical Limb Ischemia Patient Treatment: Pre-Clinical and GMP-Validation Aspects.

Advanced cell therapy medicinal products (ATMP) are at the forefront of a new range of biopharmaceuticals. The use of ATMP has evolved and increased in the last decades, representing a new approach to treating diseases that are not effectively managed with conventional treatments. The standard worldwide recognized for drug production is the Good Manufacturing Practices (GMP), widely used in the pharma production of synthesized drugs but applying also to ATMP.

[Risks and benefits of spirometry in preoperative assessment for the surgical repair of abdominal aortic aneurysm].

Since 2019, spirometry is no longer contraindicated in patients with an aneurysm of the abdominal aorta (AAA). Lung function testing has therefore become a tool for the preoperative morbidity and mortality assessment of patients eligible for surgical repair of AAA. European guidelines of anesthesiology, vascular surgery and pneumology, recommend preoperative spirometry for polymorbide patients, for whom the preoperative assessment must be as complete as possible in order to improve perioperative management and to help specialists decide of the operative mode: open (for patients with a low-risk profile) or endovascular (preferred in high-risk profile patients).

Computational Analysis of Turbulent Hemodynamics in Radiocephalic Arteriovenous Fistulas to Determine the Best Anastomotic Angles.

Background: Hemodynamics has been known to play a major role in the development of intimal hyperplasia leading to arteriovenous fistula failure. The goal of our study is to investigate the influence of different angles of side-to-end radiocephalic anastomosis on the hemodynamic parameters that promote intimal dysfunction and therefore intimal hyperplasia.

Methods: Realistic three-dimensional meshes were reconstructed using ultrasound measurements from distal side-to-end radiocephalic fistulas.

Ultrasound screening for abdominal aortic aneurysms.

Questions Under Study: This pilot study aimed to assess the feasibility, acceptance and costs of an ultrasound scan screening programme for abdominal aortic aneurysms (AAA) in the elderly male population resident in Canton Ticino, Switzerland.

Methods: The target population were male patients aged 65-80 years who attended the outpatient clinics of the Lugano Regional Hospital in 2013. The patients showing interest were contacted by phone to verify their eligibility and fix the appointment for the ultrasound scan of the abdominal aorta.

Anastomotic false aneurysm of the aorta: closure with a "sandwiched" coil.

Purpose: To describe the treatment of a noninfected saccular anastomotic false aneurysm (AFA) of the abdominal aorta with the use of a single "sandwiched" coil.

Case Report: A 65-year-old man presented with a saccular AFA of the distal anastomosis exactly at the level of the aortic bifurcation 1 month after open abdominal aortic aneurysm repair. Endograft exclusion was not attempted because an aortouni-iliac configuration would have sacrificed a patent iliac axis.

In-stent restenosis: mid-term results of debulking using excimer laser and drug-eluting balloons: sustained benefit?

Background: In-stent restenosis (ISR) after endovascular treatment of stenotic and occlusive disease of the infrainguinal arteries is still a clinical challenge. The purpose of this study is to evaluate the mid-term follow-up of a combination therapy using laser debulking and drug-eluting balloons for ISR.

Methods: A prospective cohort of 14 patients (10 female, 4 male) with clinically relevant (Rutherford 3-6) ISR who were treated with excimer-laser angioplasty and drug-eluting balloons and a clinical follow-up of at least 9 months was evaluated.

Effects of probucol versus aspirin and versus brachytherapy on restenosis after femoropopliteal angioplasty: the PAB randomized multicenter trial.

Purpose: To evaluate the effect of probucol and/or of endovascular brachytherapy (EVBT) on restenosis after percutaneous transluminal angioplasty (PTA) of femoropopliteal arteries.

Methods: A total of 335 patients (206 men; mean age 72+/-9 years) with intermittent claudication were randomized according to a 2x2 factorial design to 1 of the 4 groups: probucol, placebo, EVBT, and EVBT+probucol. Probucol (1 g/d) or placebo were given in double-blinded fashion 1 month before and for 6 months after PTA.