Publications by authors named "Retnowati W"
Article Synopsis
- The pncA gene mutations in Mycobacterium tuberculosis are linked to resistance against the antibiotic pyrazinamide (PZA), with notable differences between sensitive and resistant strains.
- The study identified three specific mutations in the resistant strain (pncAR1) that altered key amino acids, resulting in decreased enzyme activity for activating PZA.
- The findings suggest a need for further structural studies on the mutated PZase protein to better understand how these mutations contribute to drug resistance and to aid in the design of more effective tuberculosis treatments.
