Relationship between temperature variability and brain injury on magnetic resonance imaging in cooled newborn infants after perinatal asphyxia.

Objective: The objective of the study was whether temperature management during therapeutic hypothermia correlates with the severity of brain injury assessed on magnetic resonance imaging in term infants with hypoxic-ischemic encephalopathy.

Study Design: Prospectively collected register data from the National Asphyxia and Cooling Register of Switzerland were analyzed.

Result: Fifty-five newborn infants were cooled for 72 h with a target temperature range of 33 to 34 °C.

Evolution of posterior fossa and brain morphology after in utero repair of open neural tube defects assessed by MRI.

Objectives: To describe characteristics of foetuses undergoing in utero repair of open neural tube defects (ONTD) and assess postoperative evolution of posterior fossa and brain morphology.

Methods: Analysis of pre- and postoperative foetal as well as neonatal MRI of 27 foetuses who underwent in utero repair of ONTD. Type and level of ONTD, hindbrain configuration, posterior fossa and liquor space dimensions, and detection of associated findings were compared between MRI studies and to age-matched controls.