L.: A Study of Antifungal Activity against , Identification of Major Compounds, and Molecular Docking to Lanosterol 14-Alpha Demethylase.

Empirically, in Indonesia, the leaves of L. (candle bush or ketepeng cina) have been used as a topical antifungal agent. is a natural microorganism found in the human body.

Antibacterial Potency of an Active Compound from Prain: An Integrated In Vitro and In Silico Study.

Prain holds great potential as a valuable asset in pharmaceutical development. In this study, our focus is to explore and assess the antibacterial activity of various components derived from this plant, including extracts, fractions, subfractions, and isolates, explicitly targeting two common bacteria: and . The isolated compound, identified as a derivative pyridone alkaloid (5-methyl-11-(2-oxopyridin-1(2H)-yl)undecaneperoxoicacid), demonstrates notable antibacterial effects.

Isolation, Characterization, and Evaluation of Protease Activity of Crude Bromelain of Pineapple Peel, Core, and Crown from Subang District, Indonesia.

Context: Bromelain is distributed to all parts of pineapple ( (L.) Merr), including the peel, core, and crown, which are agricultural waste that has not been utilized properly.

Aims: The purpose of this study was to determine the character and protease activity of crude bromelain from the Indonesian pineapple peel, core, and crown.

Anti-Alopecia Activity of Coumarin Derivatives Isolated from Leaves and Computational Study of Their Binding to Androgen Receptors Using Molecular Docking and Molecular Dynamic Simulation.

Alopecia is a condition in which hair on the scalp or other areas of the body is lost or falls out excessively. Nutritional deficiency causes blood flow to the head to decrease causing the hormone testosterone to be changed by the enzyme 5-α-reductase to dihydrotestosterone, which inhibits the growth phase and accelerates the death phase. One of the methods developed to treat alopecia is through inhibition of the 5-α-reductase enzyme, which converts testosterone to its more potent metabolite, dihydrotestosterone (DHT).

Estrogen receptor targeting with genistein radiolabeled Technetium-99 as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation.

Objective: Genistein is an isoflavone molecule with a high affinity for estrogen receptors (ER), which could lead to the mechanism of selective estrogen receptor modulators (SERMs) in breast cancer. Genistein labeling with technetium-99 can be a new promising strategy for diagnostic breast cancer. In this research, we evaluate the physicochemical characteristics of the [Tc]Tc-genistein complex and describe the optimal labeling method parameters.

Anti-Alopecia Activity of Alkaloids Group from Noni Fruit against Dihydrotestosterone-Induced Male Rabbits and Its Molecular Mechanism: In Vivo and In Silico Studies.

Androgenic alopecia (AA) is a condition that most commonly affects adult men and is caused by an increase in the hormone dihydrotestosterone (DHT) in the hair follicles. Anti-alopecia drugs should be discovered for hair follicles to enter the anagen growth phase. Therefore, this study evaluated the hair growth-promoting activity of Noni fruit’s water, ethyl acetate, n-hexane fractions, and sub-fractions from the active fraction in the alopecia male white rabbit model.

Herbal Therapy for the Treatment of Seborrhea Dermatitis.

Seborrhea dermatitis is a skin disorder that usually appears on parts of the body that have high density of sebaceous glands, such as the face, chest, and scalp. Clinical manifestations that generally appear as scaly skin and erythema. Seborrhea dermatitis is also known as one of the causes of alopecia.

Unrevealing the Potential of Prain Fraction for the Treatment of Androgenetic Alopecia by Inhibiting Androgen Receptors Based on LC-MS/MS Analysis, and In-Silico Studies.

Androgenetic Alopecia (AGA) occurs due to over-response to androgens causing severe hair loss on the scalp, and requires the development of new and efficient drugs to treat this condition. This study explores and identifies secondary metabolites from Prain using the LC-MS/MS and in-silico method. The inhibitory activity of bioactive compounds from Prain against androgen receptors (PDB ID: 4K7A) was evaluated molecularly using docking and dynamics studies by comparing their binding energies, interactions, and stability with minoxidil.

New Hair Growth Cream Formulation with Cocoa Pod Peel ( L.).

Our previous study verified that the waste skin of cocoa ( L) fruit or waste cocoa pod husks had the efficacy to overcome hair loss or alopecia. This study aims to determine the formula and activity of hair cream of cocoa pod peel water fraction, which is effective in stimulating hair growth. Activity testing uses the modified Tanaka method.

Efficacy, Safety, and Drug-Drug Interactions for Insomnia Therapy in COVID-19 Patients.

Coronavirus disease-19 (COVID-19) is a systemic viral infection. COVID-19 patients show diverse clinical presentations ranging from asymptomatic, mild symptoms to severe symptoms characterized by severe respiratory distress. Sleep disorders or insomnia is one of the psychiatric problems that arise during the COVID-19 pandemic.

Potential anti-alopecia constituents from : An study.

Tinea capitis is local alopecia caused by a dermatophyte infection of the scalp. produces the squalene epoxidase enzyme, which has a crucial role in prolonged dermatophyte infection, as well as in synthesizing fatty acids in this dermatophyte group. This study analyzes compounds as anti-alopecia by inhibiting the squalene epoxidase enzyme formation, .

Molecular docking studies and ADME-Tox prediction of phytocompounds from as a potential anti-alopecia treatment.

Alopecia is a condition in which some or all of the hair from the scalp is lost. One recent preventative measure is the inhibition of the enzyme 5-α-reductase. Inhibition of the enzyme 5-α-reductase converts circulating testosterone to its more potent metabolite, dihydrotestosterone.

Determination of the Major Component of Water Fraction of Katuk ( (L.) Merr.) Leaves by Liquid Chromatography-Mass Spectrometry.

Background: The katuk leaf ( (L.) Merr.) is one of the plants that are used to overcome baldness by the people of Kampung Mak Kemas, Malaysia.

Antibacterial Activity Test of Extracts and Fractions of Cassava Leaves ( Crantz) against Clinical Isolates of and Causing Acne.

This study is aimed at determining antibacterial activity from ethanol extracts and the most active fraction of cassava leaves against clinical isolates of and . Research carried out by the experimental method involved determination of plants, extraction with maceration method, fractionation with liquid-liquid extraction, antibacterial activity testing of extracts and fractions by agar diffusion method, determination of most active fraction from the extract, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) testing of most active fraction by microdilution method. The results showed that ethanol extracts of cassava leaves had antibacterial activity against both bacteria with the most active fraction indicated by ethyl acetate.

Identification of compounds in the essential oil of nutmeg seeds (Myristica fragrans Houtt.) that inhibit locomotor activity in mice.

The present study was designed to evaluate the inhibitory effect of nutmeg (Myristica fragrans Houtt.) seed essential oil on the locomotor activity of mice in a wheel cage. Active compounds in the essential oil were identified by off-line solid phase extraction (SPE-C18) and GC/MS analysis.