Network Pharmacology Identifies Intersection Genes of Apigenin and Naringenin in Down Syndrome as Potential Therapeutic Targets.

Down Syndrome (DS), characterized by trisomy of chromosome 21, leads to the overexpression of several genes contributing to various pathologies, including cognitive deficits and early-onset Alzheimer's disease. This study aimed to identify the intersection genes of two polyphenolic compounds, apigenin and naringenin, and their potential therapeutic targets in DS using network pharmacology. Key proteins implicated in DS, comprising DYRK1A, APP, CBS, and ETS2, were selected for molecular docking and dynamics simulations to assess the binding affinities and stability of the protein-ligand interactions.

Unraveling Down Syndrome: From Genetic Anomaly to Artificial Intelligence-Enhanced Diagnosis.

Down syndrome arises from chromosomal non-disjunction during gametogenesis, resulting in an additional chromosome. This anomaly presents with intellectual impairment, growth limitations, and distinct facial features. Positive correlation exists between maternal age, particularly in advanced cases, and the global annual incidence is over 200,000 cases.

Multi-temporal SAR Interferometry (MTInSAR)-based study of surface subsidence and its impact on Krishna Godavari (KG) basin in India: a support vector approach.

The surface subsidence in the Krishna Godavari (KG) basin in India has increased with the discovery of crude oil and natural gas reserves since 1983. With private players coming up to bag the exploration and refining contracts, there must be timely monitoring of the surface subsidence of the region so that remedial measures for the resettlement of the populations can be taken promptly. Regular monitoring is necessary since the region is fertile and any seawater ingress results in the loss of valuable cultivable land.

Clinico-Etiological Spectrum and Outcome in Patients With Septic Acute Kidney Injury and Its Comparison With Non-septic Acute Kidney Injury: A Hospital-Based Prospective Study Conducted in a Tertiary Care Hospital in North India.

Background Acute kidney injury (AKI) is a heterogenous syndrome defined by the impairment of kidney filtration and excretory function over days to weeks, resulting in the retention of nitrogenous and other waste products normally cleared by the kidneys. In addition, AKI is frequently recognized to be associated with sepsis and contributes to an unfavorable outcome in sepsis. This study was undertaken to study and compare the etiology and clinical profile of patients with septic and non-septic AKI and to study and compare the outcome in both groups.

COVID-19 Vaccination-Related Sentiments Analysis: A Case Study Using Worldwide Twitter Dataset.

COVID-19 pandemic has caused a global health crisis, resulting in endless efforts to reduce infections, fatalities, and therapies to mitigate its after-effects. Currently, large and fast-paced vaccination campaigns are in the process to reduce COVID-19 infection and fatality risks. Despite recommendations from governments and medical experts, people show conceptions and perceptions regarding vaccination risks and share their views on social media platforms.

Association of Vascular Endothelial Growth Factor 936 C/T Gene Polymorphism with Renal Allograft Outcome: A Study from North India.

The significance of vascular endothelial growth factor (VEGF) and its polymorphisms in renal allograft rejection has recently become the subject of extensive research. Recently, some studies have shown some role of VEGF in rejection episodes and graft survival. VEGF +936 C>T polymorphism is significant in the transcription regulation of VEGF.

Vector mosquito image classification using novel RIFS feature selection and machine learning models for disease epidemiology.

Every year about one million people die due to diseases transmitted by mosquitoes. The infection is transmitted to a person when an infected mosquito stings, injecting the saliva into the human body. The best possible way to prevent a mosquito-borne infection till date is to save the humans from exposure to mosquito bites.

Diagnosis of vertebral column pathologies using concatenated resampling with machine learning algorithms.

Medical diagnosis through the classification of biomedical attributes is one of the exponentially growing fields in bioinformatics. Although a large number of approaches have been presented in the past, wide use and superior performance of the machine learning (ML) methods in medical diagnosis necessitates significant consideration for automatic diagnostic methods. This study proposes a novel approach called concatenated resampling (CR) to increase the efficacy of traditional ML algorithms.

Association of Forkhead Box P3 Gene Polymorphisms With Allograft Rejection Episodes in Kidney Transplant Patients: a Study From Kashmir, North India.

Introduction: The forkhead box P3 (FOXP3) gene is important for regulation and development of T cells, which are mediators of kidney allograft rejection. The FOXP3 gene polymorphism may be associated with the rejection of kidney transplants. This study was designed to determine the association of FOXP3 polymorphism with kidney transplant rejection.

Postpartum Acute Kidney Injury: Experience of a Tertiary Care Center.

Pregnancy-related-acute kidney injury (PR-AKI) had decreased from 40% to 20% in 1960 to <10% in recent series, mostly due to meticulous antenatal management. Postpartum-AKI (PP-AKI) resulting from late obstetric complications has become more apparent after improvement in antenatal care and legalization of medical termination of pregnancy. Women with renal injury in peripartum period admitted to our hospital over a period of 2 years (April 2013 to May 2015) were studied.

Sudden retinal vein thrombosis in a patient with nephrotic syndrome.

The authors report a sudden painless blindness in a 42-year-old male with membranous nephropathy of idiopathic origin. He was admitted with a history of decreased urine output and painful abdomen of a 3-day duration in the Department of Nephrology, Sheri Kashmir Institute of Medical Sciences, Srinagar, Kashmir - a tertiary care centre in the state of Jammu and Kashmir, India. On evaluation, he was found to have renal vein thrombosis.

Pregnancy related acute kidney injury: A single center experience from the Kashmir Valley.

All patients admitted with pregnancy related acute renal failure (PRAKI) from June 2005 to May 2007 were studied with respect to etiology, clinical features, and outcome of PRAKI. Of 569 cases of acute kidney injury (AKI), 40 (7.02%) cases were related to gestational problems; the age of the patients ranged from 15 to 45 years.

Vitamin D intoxication presenting as acute renal failure.

A 70 year-old male presented with acute renal failure and mental obtundation. On examination, he was found to have hypercalcemia and on further questioning, it was found that it was secondary to injections of a slow-release vitamin D preparation. Although total body exposure is sufficient for vitamin D synthesis, increased vitamin D deficiency secondary to poor exposure to sunlight is observed in some parts of the world.

Etiological profile of nephrotic syndrome in Kashmir.

Our study aimed to obtain a comprehensive insight into the etiology of nephrotic syndrome in our patient population. We analyzed medical records of 290 patients with diagnosis of nephrotic syndrome as defined by International Study of Kidney Disease in Children (ISKDC), between January 1987 and December 2000, at the Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar. Primary glomerular disease was found to be the most prevalent, accounting for 91.

von Recklinghausen's neurofibromatosis associated with membranous glomerulonephritis.

A 70-year old woman, known case of von Recklinghausen's neurofibromatosis presented with nephrotic syndrome and mild azotemia. Renal biopsy revealed membranous nephropathy. After ruling out secondary causes of membranous nephropathy, a possible coexistence of von Recklinghausen's neurofibromatosis and membranous nephropathy were thought of.

Nephrotic syndrome associated with transitional cell carcinoma of urinary bladder.

A 50-year-old male presented with nephrotic syndrome associated with transitional cell carcinoma of the bladder. Renal biopsy was suggestive of membranoproliferative glomerulonephritis. The proteinuria disappeared 4 weeks after the removal of tumour.

Further observations on acute renal failure following physical torture.

Thirty-four males aged 16-40 (mean 25) years in the period from August 1991 to February 1993 presented in acute renal failure (ARF), 3-14 (mean 5) days after they had been apprehended and allegedly tortured in Police interrogation centres in Kashmir. All were beaten involving muscles of the body, in addition 13 were beaten on soles, 11 were trampled over and 10 had received repeated electric shocks. Patients were studied in three groups: group I, those with evidence of only myoglobinuria (n = 21); group II, those with both myoglobinuria and haemoglobinuria (n = 10); and group III, those with evidence of only haemoglobinuria (n = 3).

Acute renal failure following physical torture.

Ten cases of acute renal failure (ARF) were seen in the period from July 1990 to August 1991 in the Nephrology Department of the SIMS Hospital, Srinagar. All were males in the age group of 18-28 years and in apparent good health when apprehended by the police. There was alleged history of physical torture of different types.