Mucosal Immunity After Novel COVID-19 Infection - Virus-Induced Immunosuppression: Preliminary Study.

In recovered COVID-19 patients, the state of mucosal immunity remains understudied. Cytological, functional, and metabolic characteristics of neutrophils and the interleukin status will help to correctly assess the need for immunorehabilitation measures. The study objective is to assess the state of mucosal immunity after COVID-19.

A simple assay for probing transformations of superparamagnetic iron oxide nanoparticles in human serum.

A novel approach for monitoring the biomolecular interactions of superparamagnetic nanoparticles was disclosed. Based on ultrafiltration of a human serum-nanoparticle mixture and the mass spectrometric analysis of filtrates, this assay revealed for iron oxide nanoparticles coated with poly(acrylic acid) satisfactory biopersistence and a bimodal binding to sulfur-containing biomolecules, with the formation of the protein corona completed in about 1 h.

Association of Toll-Like Cell Receptors TLR2 (p.Arg753GLN) and TLR4 (p.Asp299GLY) Polymorphisms with Indicators of General and Local Immunity in Patients with Atopic Dermatitis.

A whole group of polymorphisms of genes involved in the formation of the epidermal barrier, immune responses, and their regulation is important in the formation of atopic phenotype. The purpose of the study is to determine the relationship of polymorphisms of genes of Toll-like receptors TLR2 and TLR4 with clinical and immunological parameters in atopic dermatitis patients in a "case-control" study. Polymorphisms of genes TLR2 (p.

Noninvasive prenatal testing: more caution in counseling is needed in high risk pregnancies with ultrasound abnormalities.

Objective: Non-invasive prenatal testing (NIPT) is increasingly being used in prenatal aneuploidy screening. The objective of this study was to assess the positive predictive value in our cohort of 68 cases with positive NIPT result. In addition, we wondered if the use of NIPT in cases with ultrasound abnormalities is appropriate, given the limited number of chromosomes investigated.

High-resolution chromosomal microarrays in prenatal diagnosis significantly increase diagnostic power.

Objective: The objective of this study was to determine for the first time the reliability and the diagnostic power of high-resolution microarray testing in routine prenatal diagnostics.

Methods: We applied high-resolution chromosomal microarray testing in 464 cytogenetically normal prenatal samples with any indication for invasive testing.

Results: High-resolution testing revealed a diagnostic yield of 6.

[Effect of sweet pepper, enriched with selenium, on the transplantable Ehrlich carcinoma in mice].

Effect of sweet pepper enriched and non-enriched with Se on Ehrlich carcinoma growth at Balb/c mice was investigated. 1000 mg/kg of both preparations of sweet pepper (per os administration for mice of 9 months age) inhibited an early stage of tumour growth on 42-62% and 37-65% respectively. No effect on tumour growth was registered for 4 months mice.

[Results of Russian multicenter trial of immunogenicity, reactogenicity and safety of new combination vaccine against hepatitis A and B (Twinrix)].

Results of registration trial of combination vaccine for prevention of hepatitis A and B are presented. The trial was conducted in 5 centers of Russia in 2004-2005 with full accordance to good clinical practice requirements and standards for multicenter open randomized trials. Immunogenicity of studied combination vaccine Twinrix was evaluated in comparison with two simultaneously administered monovalent vaccines against hepatitis A and B (Havrix and Engerix-B) in 200 healthy subjects aged 18-40, which were seronegative to hepatitis A and B.

[The effect of various methods of preserving the fungus Aspergillus niger v. Tighem on its aggressive properties].

Using the differential-thermic and thermogravimetric methods has shown that the most promising way of fungus Aspergillus niger storing when its aggressive properties against polyamid aren't lost is to keep the culture on polymeric matter (polyamid) and in soil.

[Superoxide dismutase in Clostridium butyricum spores].

Superoxide dismutase was found for the first time in the spores of the anaerobic bacterium Clostridium butyricum. The prosthetic group of the enzyme was shown to contain iron. The enzyme was demonstrated to be highly thermostable.

Electron microscopic study of Candida tropicalis yeasts grown on a medium containing selenium.

The yeast Candida tropicalis 303 was cultivated on a medium containing selenium, and studied by electron microscopy. The vacuoles of these cells contained electron-dense granules. The correlation between the increase in the number of the electron-dense granules in the cells of C.