Effect of the Interface on the Compressibility of Substances with Spherical Nano-Inhomogeneities on the Example of Al/C.

The paper examines the compressibility of media with nano-inhomogeneities using the example of an aluminum melt and C fullerenes immersed in it. The results of molecular dynamics simulations indicate a significant effect of the interface on the effective compressibility of a heterogeneous medium. It is found that the application of the rule of mixture for the Al/C system results in an incorrect qualitative picture of the dependence of compressibility on the concentration of fullerenes.

[The effect of low frequency electrical stimulation on bone tissue regeneration].

The study was performed on 30 male rats of Wistar line (weight 330-360 g, age 3.5 months).In an experimental model of damage to the femur bone in the hip joint studied the effect of low frequency electrical stimulation of the damaged area on the rate of regeneration of bone.

[Evaluation of the immunogenic and reactogenic properties of vaccine "Euvax B" in persons aged 16-18 years in different geographical zones of Russia].

The comparative evaluation of the reactogenic and immunogenic properties of vaccine "Euvax B" in adolescents aged 16-18 years was carried out in factory housing estate Lvovsky, the Podolsk district, the Moscow region, and in the Yamalo-Nenets Autonomous District (AD): in towns Salekhard, Noyabrsk, Muravlenko, in housing estate Tarko-Sale. The evaluation demonstrated that the use of this vaccine in a dose of 20 mg/ml produced no postvaccinal complications and the frequency of postvaccinal reactions was insignificant. Postvaccinal anti-HBs were detected, on the average, in protective concentrations in 98.

[Eradication of Helicobacter pylori in patients with duodenal ulcer following the short course of treatment with azitromycin and amoxycillin].

The efficacy of short-term treatment with azithromycin in 17 patients with acute doudenal ulcer associated with H. pylori was evaluated. Bioptats of the gastric mucosa taken at the beginning and after one month of treatment were investigated for H.

[Effects of paracetamol and naproxen on pain syndromes of various genesis].

A comparative study of the effects of two nonsteroidal antiinflammatory drugs paracetamol and naproxen on the pain syndrome models of various etiology showed that paracetamol is more effective in the case of spinal and neuropathic pain syndromes (in which the leading pathogenic mechanisms are related to the formation of hyperactive neuron aggregates in the central nociceptive structures). Naproxen was effective in the case of adjuvant arthritis, for which the main development mechanism is related to the accumulation of inflammation mediators in tissues. It is concluded that special features of the pathogenic therapy of various pain syndromes are determined by the character of prostaglandin participation in the pathological process.

[Methods of Helicobacter pylori detection].

There is the HP diagnostic methods review. The classification of main methods is presented. Diagnostic significance and defects of all these methods were demonstrated.

[HGV and TTV - new hepatitis viruses].

Aim: To examine clinical, immunological and morphological features of HGV- and TTV-infections in patients with chronic hepatic diseases (CHD) and assess efficiency of treatment of HGV-seropositive patients.

Material And Methods: 202 patients with CHD were examined for markers of HBV-, HCV-, HGV- and TTV-infections. Some patients were subjected to puncture biopsy of the liver.

[Prospects of using hard dispersions in development of dosage forms for therapeutic and prophylactic use].

Thermoanalytical, chromatographic, and microscopic methods of analysis were used for identification of hard dispersions (HD) and their differences from physical mixtures (PM) by benzene PEG-4000 model systems. A complex of physiocochemical methods showed that benzonal and PEG-4000 are not thermally destroyed during simultaneous melting at 140 degrees C. Differences in thermoanalytical characteristics of PM and HD, expressed in suppression of phase transition temperatures, changes in the type of melting peaks and heats, and in the absence of drug melting peak and heats in HD vs.

[Effect of dopamine antibodies on neuropathic pain syndrome in rats].

Dopaminergic brain system plays an important role in regulation of pain sensitivity. However, the data on participation of antidopamine antibodies in the development of neurogenic pain are absent. This work was aimed at the study of the role of antidopamine antibodies in the development of pain syndrome induced by the injury of nn.

[The pathogenetic mechanisms of paroxysmal trigeminal prosopalgias].

Clinical and experimental studies of formation of paroxysmal trigeminal pain are carried out in patients with typical trigeminal neuralgia (TN), TN with neuropathic disorders, TN concomitant with disseminated sclerosis, and symptomatic TN caused by vestibulo-cochlear neurinoma (VIII pair). Trigeminal, acoustic stem, and visual evoked potentials were recorded, electroencephalography (including mapping) and magnetic imaging were carried out. In experiments, bioelectric activity of the brain was recorded in rats with TN and neuropathy.

[The possibility of Helicobacter pylori being present in the resting state in the gastric mucosa of peptic acid patients after treatment].

Aim: To develop experimental approaches to detection of inactive forms of Helicobacter pylori (HP) in patients treated for gastroduodenal ulcer, to try the role of such HP forms in emergence of ulcer recurrences.

Materials And Methods: Examination for HP was made using a fast CLO test, polymerase chain reaction (PCR), histologically. A simple quantitative spectrophotometric test for urease activity in biopsies of gastric mucosa is proposed.

[Cholestasis assessment by activity of antioxidant enzymes and composition of plasma lipoproteins in patients with liver diseases].

Aim: Investigation of activity of copper-containing enzymes in plasma superoxide dismutase (SOD) and ceruloplasmin (CP) in comparison with concentrations of lipoproteins (LP) of the main classes in patients with chronic hepatic diseases (CHD).

Materials And Methods: SOD activity, CP and LP in plasma were measured in 90 patients with CHD.

Results: An inverse relationship was found between SOD activity and CP content in CHD.

[The role of the NMDA-receptor blocker and stimulator ketamine and glycine in the development of a neuropathic pain syndrome].

The effect of glycine, ketamine, and their combination in chronic oral administration was studied on a model of the neuropathic pain syndrome. Glycine failed to prevent the pain syndrome but had a therapeutic effect. Ketamine possessed a marked preventive and therapeutic effect.

[The effect of serotonin antibodies on the development of a neuropathic pain syndrome].

Serotoninergic and catecholaminergic neurotransmitter systems of the brain play an important role in the regulation of pain sensitivity. However, there are no data on the involvement of antibodies to the above neurotransmitters is the development of neuropathic pain syndromes. The authors' studies indicated that the development of neuropathic pain syndrome occurring after nerve damage is followed by the formation of serotonin antibodies and their enhanced induction caused by immunization of animals with serotonin-protein conjugated antigen aggravates the pain syndrome.

[The effect of hydrocortisone on a neurogenic pain syndrome in rats].

The effect of hydrocortisone on the neurogenic pain syndrome induced by damage to the peripheral nerves was studied in 40 male Wistar rats. Intraperitoneal administration of 10 mg/kg of the drug caused both hyperalgesia and hypoalgesia. The direction of the hydrocortisone effect on the neurogenic pain syndrome depended on the time of administration: chronic administration before the damage to the nerves promoted the development and intensity of the syndrome; treatment applied after the nerve damage delayed the development of the syndrome.

[The treatment of the phantom pain syndrome with tizanidine].

The authors carried out estimation of analgetic effect of tisanidin by double blind test in patients with phantom limb pain syndrome. 14 patients took the medicine in a dose of 12 mg/day and 5 patients took placebo at the same dose. Characteristics and intensity of pain were estimated in accordance with McGill pain questionnaire and visual analogue scale.