Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization.

Objective: It has been reported that bipolar disorder may become less responsive to previously effective treatment with each symptomatic relapse. The primary goal of this study was to assess the rate of re-stabilization after the resumption of lithium (Li) plus divalproex (DVPX) following relapse on either agent as monotherapy.

Method: This is a prospective, 8-week, open-label outpatient Li/DVPX combination therapy trial.