No association between maternal psychological symptoms and infant outcome after pregnancy complicated by early-onset hypertensive disorders.

Aim: The aim of this work was to study the effect of maternal psychological symptoms on infant development 1 year after early-onset hypertensive disorders of pregnancy.

Methods: All mothers were enrolled in the Pre-eclampsia, Eclampsia TRial Amsterdam. Mothers were asked to complete the 90-item Symptom Check List (SCL-90) at the corrected ages of their infants of 0, 3 and 12 months.

General movements in infants born from mothers with early-onset hypertensive disorders of pregnancy in relation to one year's neurodevelopmental outcome.

Background: Assessment of general movements (GMs) at three months is considered useful for prediction of adverse neurological outcome in high risk infants.

Aims: To study the prevalence of abnormal GMs in infants born from women with early-onset hypertensive disorders of pregnancy and the association of GMs with neurodevelopmental outcome at one year.

Study Design: Prospective study, part of a randomised controlled trial of pre-birth management strategies.

Relationship between thrombophilic disorders and type of severe early-onset hypertensive disorder of pregnancy.

Objective: To determine whether specific subtypes of early-onset hypertensive disorders of pregnancy (haemolysis, elevated liver enzymes, low platelets [HELLP] syndrome; severe preeclampsia; eclampsia; and fetal growth restriction) differ in increased prevalences of thrombophilic disorders.

Design: Cohort study.

Setting: Two university hospitals in Amsterdam, the Netherlands.

One-year infant outcome in women with early-onset hypertensive disorders of pregnancy.

Objectives: To evaluate the role of plasma volume expansion on 1-year infant outcome after severe hypertensive disorders of pregnancy and to determine prognostic factors for adverse neurodevelopmental infant outcome.

Design: Randomised controlled trial, observational prognostic study.

Setting: Two university hospitals in Amsterdam, The Netherlands.

Psychosocial impact of early-onset hypertensive disorders and related complications in pregnancy.

Objective: The objective of the study was to examine the psychosocial impact of severe hypertensive disorders during pregnancy.

Study Design: All women (n = 216) in a prospective study cohort with severe hypertensive disorders of pregnancy were invited at term age, 3 months, and 1 year postterm to complete the 90-item Symptom Check List (SCL-90) questionnaire for assessment of their psychosocial condition. The association of hypothesized determinants was tested by binary logistic analysis.

Dynamics and incidence patterns of maternal complications in early-onset hypertension of pregnancy.

Objective: To describe the variable disease expression and the patterns of development of major maternal morbidity and HELLP (haemolysis, elevated liver enzymes and low platelet count) syndrome in women with different subtypes of hypertensive disorders of pregnancy.

Design: Prospective cohort study.

Setting: Two university hospitals, tertiary care centres.

Haemodynamic changes in the second half of pregnancy: a longitudinal, noninvasive study with thoracic electrical bioimpedance.

Objective: Maternal cardiovascular adaptations to pregnancy are necessary for an adequate fetomaternal circulation. However, the time course of physiological haemodynamic changes during the second half of pregnancy remains unclear. Various methods, invasive and noninvasive, are described to measure these changes.

Prediction of maternal complications and adverse infant outcome at admission for temporizing management of early-onset severe hypertensive disorders of pregnancy.

Objective: We explored the association between clinical parameters at admission and the subsequent development of major maternal complications or adverse infant outcome in women with hypertensive complications of pregnancy remote from term.

Study Design: We drew data from a randomized trial of temporizing management in 216 patients with hemolysis, elevated liver enzymes, and low platelets syndrome; severe preeclampsia; eclampsia; or hypertension-related fetal growth restriction and gestational ages between 24 and 34 completed weeks. End points were adverse infant outcome (perinatal death, severe morbidity) and major maternal complications (major morbidity; recurrent and newly acquired hemolysis, elevated liver enzymes, and low platelets; eclampsia) after admission.

A randomised controlled trial comparing two temporising management strategies, one with and one without plasma volume expansion, for severe and early onset pre-eclampsia.

Objectives: Plasma volume expansion may benefit both mother and child in the temporising management of severe and early onset hypertensive disorders of pregnancy.

Design: Randomised clinical trial. Setting Two university hospitals in Amsterdam, The Netherlands.

A randomized trial of plasma volume expansion in hypertensive disorders of pregnancy: influence on the pulsatility indices of the fetal umbilical artery and middle cerebral artery.

Objective: The purpose of this study was to investigate the effect of plasma volume expansion on the pulsatility indices of the fetal umbilical and middle cerebral arteries.

Study Design: Two hundred sixteen patients with severe preeclampsia, HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome, eclampsia, hypertension-related fetal growth restriction, and gestational ages between 24 and 34 completed weeks of gestation were assigned randomly for temporizing treatment with plasma volume expansion (n = 111 patients; 250 mL hydroxyethyl starch 6% twice daily in 4 hours, and NaCl 0.9% between doses of hydroxyethyl starch and with intravenous medication) or without plasma volume expansion (n = 105; only NaCl 0.

Plasma volume and blood pressure regulation in hypertensive pregnancy.

Background: Pre-eclampsia is a multisystem disorder, peculiar to and frequent in human pregnancy. It remains a leading cause of maternal and neonatal morbidity and mortality. Hemodynamic disturbances are the most prominent features of the syndrome.