Immunization of Broiler Chickens With a Killed Chitosan Nanoparticle Vaccine Decreases Enterica Serovar Enteritidis Load.

There is a critical need for an oral-killed vaccine for broilers. Chitosan nanoparticle (CNP) vaccines can be used to deliver antigens orally. We investigated the efficacy of a killed CNP vaccine on broilers.

Salmonella chitosan nanoparticle vaccine administration is protective against Salmonella Enteritidis in broiler birds.

Salmonella control strategies include vaccines that help reduce the spread of Salmonella in poultry flocks. In this study we evaluated the efficacy of administering a live Salmonella vaccine followed by a killed Salmonella chitosan nanoparticle (CNP) vaccine booster on the cellular and humoral immunity of broilers. The CNP vaccine was synthesized with Salmonella Enteritidis (S.