Publications by authors named "Renuka Panchagnula"
Background: Osteoporosis is characterized by microarchitectural disruption of the bone, decrease in bone mineral density, and increased skeletal fragility and risk of fracture. Osteoporosis occurs due to the decoupling of bone formation and bone resorption, with a significant increase in resorption. This review article focuses on the role of laboratory investigations in the diagnosis and monitoring of treatment in patients with osteoporosis.
View Article and Find Full Text PDFObjectives: The current study evaluated latent tuberculosis infection (LTBI) positivity in a cohort of Indian subjects and the accuracy of IFN-gamma release assay (IGRA) in predicting tuberculosis (TB) reactivation.
Methods: This cross-sectional, retrospective chart-based study considered patients diagnosed with autoimmune rheumatic diseases (AIRDs), especially those who received treatment with biologics or targeted synthetic (ts)DMARDs. The patients had undergone LTBI screening and IGRA test.
To report a rare case of skin biopsy proven Histoplasma panuveitis. Observational case report of a 76-year-old Asian Indian man presented as panuveitis. Clinical course, diagnostic and treatment difficulties and confocal microscopy findings were studied.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the neutrophil to lymphocyte ratio (NLR) as a measure of inflammation in rheumatoid arthritis (RA) patients.
- It found that NLR is more closely related to the Disease Activity Score than to traditional inflammatory markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).
- The researchers conclude that NLR could be a cost-effective and reliable inflammation marker, offering similar efficacy to CRP without being influenced by certain inflammatory cytokines.
Article Synopsis
- Type 2 diabetes mellitus (T2DM) leads to insulin resistance (IR) and can cause vascular complications despite controlled blood sugar levels.
- The study evaluated clinical, metabolic, and cytokine factors in 58 T2DM patients, categorizing them based on the severity of IR.
- Results showed that higher HbA1c and body mass index (BMI) were linked to more severe IR, while cytokines IL6 and IL10 correlated with endothelial progenitor cells (EPCs), indicating their potential role in assessing vascular risk in T2DM patients.
Background: Anticyclic citrullinated peptide (anti-CCP) is a relatively new serologic marker, which has been proposed for use in the diagnosis of rheumatoid arthritis (RA) and is said to be a highly specific.
Objective: The aim of the study was to evaluate the role of anti-CCP in a South Indian population of patients with suspected RA in the early stages when rheumatoid factor is negative and clinical presentation is atypical.
Methods: Patients with early inflammatory arthritis who were rheumatoid factor-negative were investigated for anti-CCP.