Publications by authors named "Renuka Arulthas"
Article Synopsis
- Patients undergoing thyroid surgery and receiving high doses of remifentanil often develop opioid-induced hyperalgesia (OIH), leading to increased pain sensitivity and morphine requirements post-operatively.
- The study evaluated the effects of dexmedetomidine, an α2 agonist, in reducing OIH, comparing its efficacy across different doses and between male and female patients.
- Results showed that both low- and high-dose dexmedetomidine significantly reduced pain intensity and morphine use after surgery, with fewer side effects such as chills, nausea, and vomiting in these groups compared to the control groups.
The effects of O-GlcNAc alteration on Alzheimer-like neurodegeneration in SK-N-SH cells.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
September 2018
Background: O-GlcNAcylation is a highly dynamic post-translational modification that plays a key role in regulating phosphorylation of protein and cell survival. The proteins O-GlcNAcylation level is regulated dynamically by O-GlcNAc transferase (OGT) and β-N-acetylglucosaminidase (O-GlcNAcase, OGA). Although previous studies have suggested the role of O-GlcNAcylation in neurodegenerative diseases, the mechanism of O-GlcNAcylation in Alzheimer's disease (AD) remains unclear.
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