Control-Based Continuation: A New Approach to Prototype Synthetic Gene Networks.

Control-Based Continuation (CBC) is a general and systematic method to carry out the bifurcation analysis of physical experiments. CBC does not rely on a mathematical model and thus overcomes the uncertainty introduced when identifying bifurcation curves indirectly through modeling and parameter estimation. We demonstrate, , CBC applicability to biochemical processes by tracking the equilibrium curve of a toggle switch, which includes additive process noise and exhibits bistability.

Force appropriation of nonlinear structures.

Nonlinear normal modes (NNMs) are widely used as a tool for developing mathematical models of nonlinear structures and understanding their dynamics. NNMs can be identified experimentally through a phase quadrature condition between the system response and the applied excitation. This paper demonstrates that this commonly used quadrature condition can give results that are significantly different from the true NNM, in particular, when the excitation applied to the system is limited to one input force, as is frequently used in practice.

A quality improvement initiative on the use of psychotropic drugs in nursing homes in Flanders.

Introduction: Government-funded quality improvement projects aimed to reduce the high psychotropic medication use in Belgian long-term care settings.

Design: A pilot project (2013-2014) with a pre-post and follow-up intervention design.

Methods: Two nursing homes received three educational courses.

Improved alignment and operating room efficiency with patient-specific instrumentation for TKA.

Background: Achieving accurate alignment in total knee arthroplasty (TKA) remains a concern. Patient-specific instrumentation (PSI) produced using preoperative 3D models was developed to offer surgeons a simplified, reliable, efficient and customised TKA procedure.

Methods: In this prospective study, 60 patients underwent TKA with conventional instrumentation and 71 patients were operated on using PSI.

Limitations of quantitative radionuclide bone scanning in the evaluation of total knee replacement.

To establish the value of quantitative radionuclide bone scanning after total knee replacement, 21 patients were scheduled for examination. Eight patients were scanned more than 1 year after surgery (group 1), and 13 within the first postsurgical year (group 2). Ratios were calculated for three regions of interest.

Osteoid osteoma as a cause of knee pain. A review of 10 cases.

Osteoid osteoma is a benign tumor frequently situated around the knee. It should therefore be considered as a possible cause of atraumatic knee pain in young adults. The mean interval from onset of symptoms to diagnosis is 14 months.

Correlation between magnetic resonance imaging and arthroscopy in the diagnosis of anterior cruciate ligament and meniscus lesions.

In both radiological and orthopedic journals the value of MRI for diagnosing internal derangement of the knee has been assessed recently. However, results vary widely and no study reports on the differentiation among types of ACL tears. As far as meniscal pathology is concerned, attention has been drawn by Reicher et al.

The accident-prone and overuse-prone profiles of the young athlete.

A 1 year prospective study was done to develop an accident-prone and overuse-prone profile of young athletes. A group of 185 freshman physical education students (118 males; 67 females of the same age (18.3 +/- 0.