Publications by authors named "Renske De Zwaef"
Article Synopsis
- Many people with major depressive disorder (MDD) don't get better with regular antidepressant treatments, especially if they've tried four different ones or have been dealing with depression for over two years.
- VNS Therapy is a special treatment that can help these patients, but it needs special clinics with trained professionals.
- This text explains how to set up VNS Therapy services, including creating a team of healthcare workers, educating patients, and making sure everything is done the right way.
Background: Depressive illness is associated with significant adverse consequences for patients and their families, and for society. Clinical challenges are encountered in the management of patients suffering from depression whether they are designated difficult-to-treat or treatment-resistant. Prospective serial depression treatment trials have shown that less than 40% of patients with major depressive disorder remit with an initial pharmacotherapy trial, and a progressively smaller proportion of patients remit with each subsequent trial.
View Article and Find Full Text PDFSepsis and septic shock result from an exacerbated systemic inflammatory reaction to infection. Their incidence is rising, and they have recently become the main cause of death in intensive care units. Septic shock is defined as sepsis accompanied by life-threatening refractory hypotension, for which excessive nitric oxide (NO), produced by inducible NO synthase iNOS, is thought responsible.
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