Purpose: To investigate the clinical relevance and biological function of the kinesin super-family protein 4A (KIF4A) expression in prostate cancer (PCa).
Methods: We examined 1) the relationship between the expression of KIF4A and clinico-pathological characteristics of PCa patients using a tissue microarray and the Cancer Genome Atlas database, 2) the prognostic value of KIF4A expression in patients using Kaplan-Meier plots and 3) the functions of KIF4A in LNCaP and DU145 cells, such as cell proliferation, cell cycle and cell apoptosis.
Results: Compared with normal prostate, the mRNA and protein expressions of KIF4A were up-regulated in PCa.
Background: Prostate cancer (PCa) is the most common malignancy seen in men and the second leading cause of cancer-related death in males. The incidence and mortality associated with PCa has been rapidly increasing in China recently.
Methods: Multiple diagnostic models of human PCa were developed based on Taylor database by combining the artificial neural networks (ANNs) to enhance the ability of PCa diagnosis.
Objective: To investigate the mediation effect of approach/avoidance motivation between hardiness and depressive symptoms.
Methods: Cross-sectional design was utilized. Two independent samples of military servicemen (G1: military personnel in the Armed Forces; G2: Chinese army military cadets) (n1 = 98, n2 =140) were sampled and investigated.
Background: This study aimed to develop and conduct psychometric testing of the Critical Thinking Disposition Inventory to measure the critical thinking disposition of Chinese medical college students.
Methods: The study was conducted in two stages: (a) item generation, reliability analysis and exploratory factor analysis (EFA) and (b) confirmatory factor analysis (CFA) and testing of psychometric properties (Cronbach' s alpha, test-retest reliability and convergent validity). The subjects included 1035 Chinese medical college students.