Side Chain Phenyl Isomerization-Induced Spatial Conjugation for Achieving Efficient Near-Infrared II Phototheranostic Agents.

The contradiction of near-infrared II (NIR-II) emission and photothermal effects limits the development of phototheranostic agents (PTAs) in many emerging cutting-edge applications. Organic aggregates present a promising opportunity for the balance of competitive relaxation processes through the manipulation of molecular structure and packing. Herein, side chain phenyl isomerization-induced spatial conjugation was proposed for constructing A-D-A type NIR-II PTAs with simultaneous enhancement of fluorescence brightness and photothermal properties.

Thiophene assisted cellular uptake enhancement for highly efficient NIR-II cancer phototheranostics.

We designed two series of NIR-II PTAs with D-A or D-A-D structures, in which the introduction of thiophene promotes a bathochromic shift of emission into the NIR-II region, helps to improve the cellular uptake of the PTAs and facilitates NIR-II imaging-guided PDT/PTT cancer phototherapy.

Sulfur oxidation states manipulate excited state electronic configurations for constructing highly efficient organic type I photosensitizers.

The multiple relaxation processes of excited states are a bridge connecting molecular structures and properties, providing enormous application potential for organic luminogens. However, a systematic understanding and manipulation of the relationship between the molecular structure, excited state relaxation processes, and properties of organic luminogens is still lacking. Herein, we report a strategy for manipulating excited state electronic configurations through the regulation of the sulfur oxidation state to construct eminent organic type I PSs.