CYP2C19 Poor Metabolizer Status and High System Inflammation Response Index are Independent Risk Factors for Premature Myocardial Infarction: A Hospital-Based Retrospective Study.

Objective: Atherosclerosis (AS) is a sustained chronic vascular inflammatory response caused by lipid metabolism disorders and immune response disorders and is the main cause of premature (men ≤ 55 years old, women ≤ 65 years old) myocardial infarction (PMI). Cytochrome P450 2C19 (CYP2C19) (related to vascular function and lipid metabolism) and peripheral immune cell levels and plays an important role in the course of AS. The association polymorphisms, comprehensive immunoinflammatory indices with PMI susceptibility is unclear.

E2/E3 and E3/E4 Genotypes of the Apolipoprotein E are Associated with Higher Risk of Diabetes Mellitus in Patients with Hypertension.

Objective: Apolipoprotein E (APOE) plays an important role in the lipid metabolism. polymorphisms have been implicated in susceptibility to diabetes mellitus (DM). However, the association between polymorphisms and the risk of DM among the hypertensive patients remains unclear.