Correction: Calcium-Activated-Calcineurin Reduces the In Vitro and In Vivo Sensitivity of Fluconazole to Candida albicans via Rta2p.

[This corrects the article DOI: 10.1371/journal.pone.

Precise and Omnidirectional Opto-Thermo-Elastic Actuation in Van Der Waals Contacting Systems.

Actuation of micro-objects along unconstrained trajectories in van der Waals contacting systems-in the same capacity as optical tweezers to manipulate particles in fluidic environments-remains a formidable challenge due to the lack of effective methods to overcome and exploit surface friction. Herein, a technique that aims to resolve this difficulty is proposed. This study shows that, by utilizing a moderate power beam of light, micro-objects adhered on planar solid substrates can be precisely guided to move in arbitrary directions, realizing sub-nanometer resolution across extended surfaces.

Monitoring and Analysis of Prestress Loss in Prestressed Box Girder Bridges Strengthened with External Prestressing.

To investigate the effects of long-term prestress loss on concrete box girders strengthened with external prestressing, a large-span box girder, in service for over 20 years and strengthened with external prestressing, was monitored for four months. Prestress loss in the longitudinal, vertical, and transverse directions of the box girder was calculated according to Chinese code requirements. Magnetic flux rope force transducers were used to monitor the prestress loss in the external prestressing cables.

Electrostatic Force-Assisted Transfer of Flexible Silicon Photodetector Focal Plane Arrays for Image Sensors.

Flexible photodetectors are pivotal in contemporary optoelectronic technology applications, such as data reception and image sensing, yet their performance and yield are often hindered by the challenge of heterogeneous integration between photoactive materials and flexible substrates. Here, we showcase the potential of an electrostatic force-assisted transfer printing technique for integrating Si PIN photodiodes onto flexible substrates. This clean and dry process eliminates the need for chemical etchants, making it a highly desirable method for manufacturing high-performance flexible photodetector arrays, expanding their widespread applications in electronic eyes, robotics, and human-machine interaction.

Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species-activated P38 MAPK signal pathway.

The involvement of inwardly rectifying potassium channel 4.1 (Kir4.1) in neuropathic pain has been established.

Alternative Oxidase: From Molecule and Function to Future Inhibitors.

In the respiratory chain of the majority of aerobic organisms, the enzyme alternative oxidase (AOX) functions as the terminal oxidase and has important roles in maintaining metabolic and signaling homeostasis in mitochondria. AOX endows the respiratory system with flexibility in the coupling among the carbon metabolism pathway, electron transport chain (ETC) activity, and ATP turnover. AOX allows electrons to bypass the main cytochrome pathway to restrict the generation of reactive oxygen species (ROS).

Mechanisms of calcium homeostasis orchestrate plant growth and immunity.

Calcium (Ca) is an essential nutrient for plants and a cellular signal, but excessive levels can be toxic and inhibit growth. To thrive in dynamic environments, plants must monitor and maintain cytosolic Ca homeostasis by regulating numerous Ca transporters. Here we report two signalling pathways in Arabidopsis thaliana that converge on the activation of vacuolar Ca/H exchangers (CAXs) to scavenge excess cytosolic Ca in plants.

Ultra-thin, zoom capable, flexible metalenses with high focusing efficiency and large numerical aperture.

The ever-growing demand for miniaturized optical systems presents a significant challenge in revolutionizing their core element - the varifocal lens. Recent advancements in ultra-thin, tunable metasurface optics have introduced new approaches to achieving zoom imaging. However, current varifocal metalens have faced challenges such as low focusing efficiency, limited tunability, and complicated designs.

TORC pathway intersects with a calcium sensor kinase network to regulate potassium sensing in .

Potassium (K) is an essential macronutrient for plant growth, and its availability in the soil varies widely, requiring plants to respond and adapt to the changing K nutrient status. We show here that plant growth rate is closely correlated with K status in the medium, and this K-dependent growth is mediated by the highly conserved nutrient sensor, target of rapamycin (TOR). Further study connected the TOR complex (TORC) pathway with a low-K response signaling network consisting of calcineurin B-like proteins (CBL) and CBL-interacting kinases (CIPK).

Three-Dimensional Printed Tooth Model with Root Canal Ledge: A Novel Educational Tool for Endodontic Training.

Ledge formation presents a significant challenge in endodontic treatment. Yet, there is still a lack of educational tooth models for hands-on practice. This study aimed to create and evaluate a tooth model for ledge management practice.

The medicinal plant used in the Guangxi Fangcheng Golden Camellias national nature reserve, a coastal region in southern China.

Backgrounds: Guangxi Fangcheng Golden Camellias national nature reserve, situated in Fangcheng City, Guangxi Province, China, is a coastal region renowned for its exceptional natural environment. Over time, the residents of this area have acquired extensive knowledge regarding medicinal plants, owing to their close association with the abundant flora. Our study aims to document the medicinal plants used by the local community near the Guangxi Fangcheng Golden Camellias national nature reserve.

Two-dimensional heterostructure quasi-BIC photonic crystal surface-emitting laser with low divergence.

High beam quality, large-area output, and small footprint are significant pursuing goals for vertical-cavity surface-emitting lasers (VCSELs), which impose strict requirements on tight light confinements with minimized radiation losses. To achieve this, bound states in the continuum (BICs) have been demonstrated as an effective way of trapping light. Here, we combine BICs and photonic bandgaps to realize a quasi-BIC single-mode photonic crystal (PhC) laser on a colloidal quantum dots (CQDs)/silicon oxide (SiO) hybrid integrated platform.

Advances in novel devices for the treatment of heart failure.

Heart failure (HF) is one of the leading causes of global health impairment. Current drugs are still limited in their effectiveness in the treatment and reversal of HF: for example, drugs for acute HF (AHF) help to reduce congestion and relieve symptoms, but they do little to improve survival; most conventional drugs for HF with preserved ejection fraction (HFpEF) do not improve the prognosis; and drugs have extremely limited effects on advanced HF. In recent years, progress in device therapies has bridged this gap to a certain extent.

Potassium nutrient status drives posttranslational regulation of a low-K response network in Arabidopsis.

Under low-potassium (K) stress, a Ca signaling network consisting of calcineurin B-like proteins (CBLs) and CBL-interacting kinases (CIPKs) play essential roles. Specifically, the plasma membrane CBL1/9-CIPK pathway and the tonoplast CBL2/3-CIPK pathway promotes K uptake and remobilization, respectively, by activating a series of K channels. While the dual CBL-CIPK pathways enable plants to cope with low-K stress, little is known about the early events that link external K levels to the CBL-CIPK proteins.

Flexible passive integrated photonic devices with superior optical and mechanical performance.

Flexible integrated photonics is a rapidly emerging technology with a wide range of possible applications in the fields of flexible optical interconnects, conformal multiplexing sensing, health monitoring, and biotechnology. One major challenge in developing mechanically flexible integrated photonics is the functional component within an integrated photonic circuit with superior performance. In this work, several essential flexible passive devices for such a circuit were designed and fabricated based on a multi-neutral-axis mechanical design and a monolithic integration technique.

Two transporters mobilize magnesium from vacuolar stores to enable plant acclimation to magnesium deficiency.

Magnesium (Mg) is an essential metal for chlorophyll biosynthesis and other metabolic processes in plant cells. Mg is largely stored in the vacuole of various cell types and remobilized to meet cytoplasmic demand. However, the transport proteins responsible for mobilizing vacuolar Mg2+ remain unknown.

Stress-associated developmental reprogramming in moss protonemata by synthetic activation of the common symbiosis pathway.

Symbioses between angiosperms and rhizobia or arbuscular mycorrhizal fungi are controlled through a conserved signaling pathway. Microbe-derived, chitin-based elicitors activate plant cell surface receptors and trigger nuclear calcium oscillations, which are decoded by a calcium/calmodulin-dependent protein kinase (CCaMK) and its target transcription factor interacting protein of DMI3 (IPD3). Genes encoding CCaMK and IPD3 have been lost in multiple non-mycorrhizal plant lineages yet retained among non-mycorrhizal mosses.

Conserved mechanism for vacuolar magnesium sequestration in yeast and plant cells.

Magnesium (Mg) is an essential nutrient for all life forms. In fungal and plant cells, the majority of Mg is stored in the vacuole but mechanisms for Mg transport into the vacuolar store are not fully understood. Here we demonstrate that members of ancient conserved domain proteins (ACDPs) from Saccharomyces cerevisiae and Arabidopsis thaliana function in vacuolar Mg sequestration that enables plant and yeast cells to cope with high levels of external Mg.

Four plasma membrane-localized MGR transporters mediate xylem Mg loading for root-to-shoot Mg translocation in Arabidopsis.

Magnesium (Mg), an essential structural component of chlorophyll, is absorbed from the soil by roots and transported to shoots to support photosynthesis in plants. However, the molecular mechanisms underlying root-to-shoot Mg translocation remain largely unknown. We describe here the identification of four plasma membrane (PM)-localized transporters, named Mg release transporters (MGRs), that are critical for root-to-shoot Mg transport in Arabidopsis.

Seedling Lethal 1 Interacting With Plastid-Encoded RNA Polymerase Complex Proteins Is Essential for Chloroplast Development.

Mitochondrial transcription termination factors (mTERFs) are highly conserved proteins in metazoans. Plants have many more mTERF proteins than animals. The functions and the underlying mechanisms of plants' mTERFs remain largely unknown.

Genome-Wide Analysis of the Five Phosphate Transporter Families in and Their Expressions in Response to Low-P.

Phosphate transporters (PHTs) play pivotal roles in phosphate (Pi) acquisition from the soil and distribution throughout a plant. However, there is no comprehensive genomic analysis of the PHT families in , an emerging oilseed crop. In this study, we identified 73 CsPHT members belonging to the five major PHT families.

Author Correction: A calcium signalling network activates vacuolar K remobilization to enable plant adaptation to low-K environments.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.