Enhanced iodinated disinfection byproducts formation in iodide/iodate-containing water undergoing UV-chloramine sequential disinfection: Machine learning-aided identification of reaction mechanisms.

Restricted to the complex nature of dissolved organic matter (DOM) in various aquatic environments, the mechanisms of enhanced iodinated disinfection byproducts (I-DBPs) formation in water containing both I and IO (designated as I/IO in this study) during the ultraviolet (UV)-chloramine sequential disinfection process remains unclear. In this study, four machine learning (ML) models were established to predict I-DBP formation by using DOM and disinfection features as input variables. Extreme gradient boosting (XGB) algorithm outperformed the others in model development using synthetic waters and in cross-dataset generalization of surface waters.

Mixed chlorine/chloramines in disinfected water and drinking water distribution systems (DWDSs): A critical review.

Mixed chlorine/chloramines are commonly occurring in real drinking water distribution systems (DWDSs) but often overlooked. This review provides a comprehensive overview of the occurrences, characteristics, analysis methods, and control strategies of mixed chlorine/chloramines in DWDSs. The characteristics of mixed chlorine/chloramine species are summarized for treated water in drinking water treatment plants (DWTPs), secondary disinfection facilities, and DWDSs where different disinfectants could be blended.

Pyroptosis in health and disease: mechanisms, regulation and clinical perspective.

Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic lysis, resulting in cytomembrane rupture and release of immunostimulatory components, which play a role in several pathological processes. Significant cellular responses to various stimuli involve the formation of inflammasomes, maturation of inflammatory caspases, and caspase-mediated cleavage of gasdermin. The function of pyroptosis in disease is complex but not a simple angelic or demonic role.

Overlooked Role of Fungi in Drinking Water Taste and Odor Issues.

Taste and odor (T&O) are among the most frequently encountered aesthetic issues in drinking water. While fungi have been reported to produce offensive odors, their contribution to T&O in drinking water remains understudied and often overlooked. In this study, the profiles of fungal community and odorants produced by 10 native fungal isolates were investigated in 36 samples collected from two drinking water treatment plants and a premise plumbing system.

Pyrazine-based iron metal organic frameworks (Fe-MOFs) with modulated O-Fe-N coordination for enhanced hydroxyl radical generation in Fenton-like process.

Rational design of coordination environment of Fe-based metal-organic frameworks (Fe-MOFs) is still a challenge in achieving enhanced catalytic activity for Fenten-like advanced oxidation process. Here in, novel porous Fe-MOFs with modulated O-Fe-N coordination was developed by configurating amino terephthalic acid (HATA) and pyrazine-dicarboxylic acid (PzDC) (Fe-ATA/PzDC-7:3). PzDC ligands introduce pyridine-N sites to form O-Fe-N coordination with lower binding energy, which affect the local electronic environment of Fe-clusters in Fe-ATA, thus decreased its interfacial HO activation barrier.

S3-Net: A Self-Supervised Dual-Stream Network for Radiology Report Generation.

Intelligent medicine is eager to automatically generate radiology reports to ease the tedious work of radiologists. Previous researches mainly focused on the text generation with encoder-decoder structure, while CNN networks for visual features ignored the long-range dependencies correlated with textual information. Besides, few studies exploit cross-modal mappings to promote radiology report generation.

Small extracellular vesicles: a novel drug delivery system for neurodegenerative disorders.

Neurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood-brain barrier (BBB), which makes it difficult to find effective treatments and drugs, causing great stress and financial burden to families and society. Currently, small extracellular vesicles (sEVs) are the most promising drug delivery systems (DDSs) for targeted delivery of molecules to specific sites in the brain as a therapeutic vehicle due to their low toxicity, low immunogenicity, high stability, high delivery efficiency, high biocompatibility and trans-BBB functionality.

Efficient Preparation of a Magnetic Helical Carbon Nanomotor for Targeted Anticancer Drug Delivery.

The applications of nanomotors in the biomedical field have been attracting extensive attention. However, it remains a challenge to fabricate nanomotors in a facile way and effectively load drugs for active targeted therapy. In this work, we combine the microwave heating method and chemical vapor deposition (CVD) to fabricate magnetic helical nanomotors efficiently.

Insight into mixed chlorine/chloramines conversion and associated water quality variability in drinking water distribution systems.

Mixed chlorine/chloramines are common in drinking water distribution systems (DWDSs); however, their transformation and impact on chemical and microbial characteristics are not well understood. We systematically investigated water quality parameters associated with mixed chlorine/chloramine species conversion in 192 samples (including raw, finished, and tap water) collected throughout the year in a city in East China. Various chlorine/chloramine species (free chlorine, monochloramine [NHCl], dichloramine [NHCl], and organic chloramines [OC]) were detected in both chlorinated and chloraminated DWDSs.

microRNAs profiling of small extracellular vesicles from midbrain tissue of Parkinson's disease.

Small extracellular vesicles (sEVs) are generated by all types of cells during physiological or pathological conditions. There is growing interest in tissue-derived small extracellular vesicles (tdsEVs) because they can be isolated from a single tissue source. Knowing the representation profile of microRNA (miRNA) in midbrain tissue-derived sEVs (bdsEVs) and their roles is imperative for understanding the pathological mechanism and improving the diagnosis and treatment of Parkinson's disease (PD).

Cultivation-dependent and cultivation-independent investigation of O-methylated pollutant-producing bacteria in three drinking water treatment plants.

O-methylated pollutants (OMPs) are emerging contaminants in drinking water and mainly produced through bacterial O-methylation. However, the information of OMP-producing bacteria (OMPPB) in drinking water treatment plant (DWTP) is largely unknown so far. In this study, the OMPPB in water samples from three DWTPs (XL, JX and NX) were investigated by using cultivation-dependent and cultivation-independent technologies.

Sequential combination of pre-chlorination and powdered activated carbon adsorption on iodine removal and I-THMs control in drinking water.

Combining pre-oxidation with activated carbon adsorption was explored as an ideal approach for removing iodine from water source to eliminate the formation of Iodinated trihalomethanes (I-THMs). Compared with permanganate and monochloramine, chlorine is more suitable as pre-oxidant to obtain higher active iodine species (HOI/I). Active iodine species adsorption using both powdered activated carbon (PAC) and granular activated carbon (GAC) can be well fitted the pseudo-second-order kinetic model indicating that chemical adsorption was the dominant mechanism for HOI/I adsorption.

Pilot investigation on biostability of drinking water distribution systems under water source switching.

Water quality deterioration of drinking water distribution systems (DWDSs) caused by water source switching has been reported previously. However, systematic investigation of the biostability of DWDS under water source switching is limited. Aged pipes, including three commonly used pipe materials dug out from a practical DWDS, were used to systematically investigate the biofilm stability mechanism of DWDS under water source switching to quality-improved water.

Joint majorization of waterworks and secondary chlorination points considering the chloric odor and economic investment in the DWDS using machine learning and optimization algorithms.

The traditional methods of increasing the chlorine disinfectant dosage in the drinking water distribution system (DWDS) to control microorganisms and improve the safety of drinking water quality are subjected to several challenges. One noticeable problem is the unpleasant odor generated by chlorine and chloramines. However, the generally proposed chlorine dosage optimization model ignores the chloric odor distribution in the DWDS.

Characteristics of biostability of drinking water in aged pipes after water source switching: ATP evaluation, biofilms niches and microbial community transition.

Delivering quality-changed water often contributes to the biological instability of drinking water distribution systems (DWDS). However, the potential effects of quality-changed water on the biostability within DWDS are not well understood, especially after water switching to quality-improved water. The objective of this study was to investigate the effects of quality-improved water on DWDS, focusing on the stability of biofilm.

Biotransformation of halophenols into earthy-musty haloanisoles: Investigation of dominant bacterial contributors in drinking water distribution systems.

Microorganisms in drinking water distribution systems (DWDSs) can O-methylate toxic halophenols (HPs) into earthy-musty haloanisoles (HAs). However, the dominant HA-producing bacterial species and their O-methylation properties are still unknown. In this study, eight bacterial strains from DWDS were isolated and the community abundances of the related genera in bulk water and biofilms as well as their O-methylation properties were investigated.

Algae-induced taste and odour problems at low temperatures and the cold stress response hypothesis.

The existence of taste and odour (T&O) in drinking water is one of the principal causes of consumer complaints and is commonly related to algae growth. Numerous studies have confirmed the existence of algal blooms emerging specifically in low-temperature periods, herein referred to as "cold algae"; these include chrysophytes, cryptophytes, dinoflagellates and diatoms. In addition, the adaption mechanisms of these "cold algae" involve high flexibility in their nutrient intake and to the hydrological characteristics of the waters and their high contents of intracellular polyunsaturated fatty acids (PUFAs).

Interspecific competition between Microcystis aeruginosa and Pseudanadaena and their production of T&O compounds.

Microcystis aeruginosa and Pseudanabaena are two common cyanobacterial species/genus and they can occur coincidently in many eutrophic lakes globally. These two cyanobacteria could produce Taste & Odor (T&O) compounds, and their production of T&O compounds might be changed when they are present coincidently. The amounts of T&O compounds and their producers may influence the effectiveness of water treatment processes.

Formation of odorant haloanisoles and variation of microorganisms during microbial O-methylation in annular reactors equipped with different coupon materials.

Taste and odor (T & O) issues in drinking water have become serious problems which cannot be ignored by customers. Several studies have confirmed that microbes in water can biotransform halophenols (HPs) to haloanisoles (HAs) with earthy and musty flavors via microbial O-methylation. In this paper, the formation of 2-chloroanisole (2-CA), 2,4-dichloroanisole (2,4-DCA), 2,4,6-trichloroanisole (2,4,6-TCA), 2,3,6-trichloroanisole (2,3,6-TCA) and 2,4,6-tribromoanisole (2,4,6-TBA), and the microbial variation during the microbial O-methylation were investigated in annular reactors (ARs) with three coupon materials.

A novel method: using an adenosine triphosphate (ATP) luminescence-based assay to rapidly assess the biological stability of drinking water.

The rapid and credible evaluations of the microbial stability of a drinking water distribution system (DWDS) are of great significance for ensuring the safety of drinking water and predicting microbial pollution. Conventional biostability assessment methods mainly focus on bacterial regrowth or evaluation of the level of nutrients that support bacterial regrowth. However, such methods are time-consuming and have many limitations.