Deceiving duodenal erosion: a fishbone lies beneath.

Incidental identification of foreign body (FB) during daily screening endoscopy is not rare. The patients may have unspecific symptoms and do not report a history of FB ingestion at presentation. Although these FBs mostly pass through the gastrointestinal tract uneventfully, a certain proportion could be impacted and cause complications.

A rare complication of prophylactical clip closure after colonic endoscopic submucosal dissection.

Prophylactic defect closure has been considered to prevent delayed bleeding after polypectomy. However, recent evidence has demonstrated its beneficial effect is limited to those ≥20 mm proximal nonpedunculated lesions. Despite this, prophylactic defect closure is widely performed in clinical practice after colonic endoscopic submucosal dissection (ESD).

Endoscopic or Follow-up Treatment for Gastric Indeterminate Tumors Is the Preferred Method of Management.

Background: Endoscopic forceps biopsy (EFB) lacks precision in diagnosing indeterminate tumors. When the presence of early gastric cancer (EGC) is macroscopically suspected, but biopsy pathology fails to give a diagnosis of neoplasia, it causes problems in clinical management. The purpose of this study was to discuss the outcome of gastric indeterminate tumors and the clinical factors associated with predicting EGC.

Antiproliferative effect of resveratrol in pancreatic cancer cells.

To investigate resveratrol, one of the food derived polyphenols that might be partially responsible for the beneficial effect on cancer, the in vitro antitumor activity of resveratrol against pancreatic cancer cell lines (PANC-1, BxPC-3 and AsPC-1) was examined, together with the mechanisms involved. The effects of resveratrol on the growth inhibition, apoptosis and cell cycle were assayed. The activity of caspases and the expression of Bcl-2, Bcl-xL, XIAP and Bax protein were detected.

[Significance of IL-1beta-induced ectopic expression of CDX2 in the intestinal metaplasia of gastric epithelium].

Objective: To evaluate the effect of IL-1beta on the expression of CDX2 in human gastric epithelial cell line GES-1 and its role in the intestinal metaplasia.

Methods: GES-1 cells were treated with IL-1beta in different concentrations and the expressions of CDX2 mRNA and protein were detected by real-time PCR, immunocytochemistry and Western blot at different time points. GES-1 cells were then pre-treated with NF-KappaB pathway inhibitor PDTC, and the expression of CDX2 mRNA and protein induced by IL-1beta were detected.

The CCL21/CCR7 pathway plays a key role in human colon cancer metastasis through regulation of matrix metalloproteinase-9.

Purpose: CC chemokine receptor 7 (CCR7) and matrix metalloproteinase-9 (MMP-9) have been associated with lymph node metastasis in human colon cancer. Studies have suggested a potential link between CCR7 and MMP-9 in cancer; however, the molecular mechanism by which C-C ligand 21/CCR7 promotes tumour dissemination in human colon cancer is not well understood. Thus, we aimed to determine whether MMP-9 is regulated by the C-C ligand 21/CCR7 in human colon cancer.

[Role of CCL21/CCR7 in invasion of colorectal carcinoma cell line SW480].

Background And Objective: Chemokine receptor CCR7 is up-regulated in gastrointestinal carcinomas and is significantly associated with lymphatic invasion and lymph node metastasis. This study was to investigate the role and mechanism of CCL21/CCR7 in invasion of colorectal carcinoma cell line SW480.

Methods: The invasive capacity of SW480 cells was examined using Wound healing assay and Transwell assay.

Can an allograft become harmonious with its recipient by analogous mechanisms to the long-term survival of a parasite in its host? Transplantation is similar to parasitism and chronic parasite infection can prolong allograft survival.

Organ transplantation is very similar to the parasitism, the immune responses to the allograft and parasite share some general characters in acute stage. But host-parasite interplay seems harmonious and clinically asymptomatic carriers act as long-term reservoirs for transmission even several decades. It is proposed that the allograft also can survive long-term like the parasite harmonious with the host if we exploit the mechanism of the parasitism.