Publications by authors named "Renhao Ni"
Constructing tissue/organ analogs with natural structures and cell types in vitro offers a valuable strategy for the in situ repair of damaged tissues/organs. Three-dimensional (3D) bioprinting is a flexible method for fabricating these analogs. However, extrusion-based 3D bioprinting faces the challenge of balancing the use of soft bioinks with the need for high-fidelity geometric shapes.
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- * Current scaffold designs primarily focus on two-dimensional cell alignment, failing to achieve the necessary three-dimensional structure needed to restore muscle function.
- * The introduction of an iron oxide-embedded hydrogel that promotes 3D cell alignment and differentiation shows promise for improving muscle tissue regeneration and connectivity, offering an innovative solution for treating muscle-related diseases.
Article Synopsis
- Pancreatic cancer is hard to detect early, leading to poor treatment responses; a new study proposes a method using advanced technology to improve early detection and monitoring.* -
- The method includes a combination of single-cell capturing, tumor-targeted silver nanoparticles, and specialized fiber optics with Raman spectroscopy, which enhances signal clarity and reduces noise.* -
- Findings show that this approach successfully identifies molecular changes in pancreatic cancer cells and highlights important cellular components, making it a promising tool for faster and more accurate diagnosis.*
Early screening for pathogens is crucial during pandemic outbreaks. Nucleic acid testing (NAT) is a valuable method for keeping pathogens from spreading. However, the long detection time and large size of the instruments involved significantly limited the efficiency of detection.
View Article and Find Full Text PDFFOXD1, a new member of the transcription factor family, serves as a mediator and biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma (UVM) is unclear. This study demonstrated that might promote tumor growth and invasion, because expression was negatively correlated with overall survival, progression-free survival, and disease-specific survival in UVM patients.
View Article and Find Full Text PDFEngineered scaffolds are used for repairing damaged esophagus to allow the precise alignment and movement of smooth muscle for peristalsis. However, most of these scaffolds focus solely on inducing cell alignment through directional apparatus, often overlooking the promotion of muscle tissue formation and causing reduced esophageal muscle repair effectiveness. To address this issue, we first introduced aligned nano-ferroferric oxide (FeO) assemblies on a micropatterned poly(ethylene glycol) (PEG) hydrogel to form micro-/nano-stripes.
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- The human amniotic membrane (hAM) is a vital part of the placenta, known for its biocompatibility and potential in regenerative medicine due to its unique structure and bioactive components.
- The review covers the biological properties of hAM-derived cells, emphasizing their stemness and potential as a valuable source of stem cells for tissue regeneration.
- It discusses methods for collecting, preparing, preserving, and decellularizing hAM while also noting recent advancements aimed at improving its effectiveness for therapeutic applications, with a call for further research on modifications to enhance its utility.
The treatment of gastric ulcer and perforation using synthetic and biomaterials has been a clinical challenge. In this work, a drug-carrying layer of hyaluronic acid was combined with a gastric submucosal decellularized extracellular matrix called gHECM. The regulation of macrophage polarization by the extracellular matrix's components was then investigated.
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- Macrophages have two main types, M1 (pro-inflammatory) and M2 (anti-inflammatory), that play a crucial role in inflammation and often coexist during the inflammation process.
- This paper explores how macrophages interact with other cells and tissues in inflammation-related diseases and discusses the signaling pathways involved in their transition between phenotypes.
- The research proposes new therapeutic strategies to manage inflammation by monitoring macrophage phenotype changes, aiming to reduce reliance on long-term antibiotic treatments and improve outcomes for diseases such as pneumonia.
(1) Background: Reconstruction of Achilles tendon defects and prevention of postoperative tendon adhesions were two serious clinical problems. In the treatment of Achilles tendon defects, decellularized matrix materials and mesenchymal stem cells (MSCs) were thought to address both problems. (2) Methods: In vitro, cell adhesion, proliferation, and tenogenic differentiation of tendon-derived stem cells (TDSCs) on small intestinal submucosa (SIS) were evaluated.
View Article and Find Full Text PDFThe Promising Hydrogel Candidates for Preclinically Treating Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis.
Adv Wound Care (New Rochelle)
January 2023
Article Synopsis
- - Diabetic foot ulcers (DFUs) have high amputation rates due to poor healing, and while traditional dressings are ineffective, functional hydrogels show promise as a new treatment method, but more evidence is needed.
- - A meta-analysis, following PRISMA and CONSORT guidelines, analyzed 24 animal studies and 6 clinical trials, finding that functional hydrogels significantly speed up DFU healing and improve patient symptoms, categorizing them into various types based on their specific functions.
- - The analysis suggests that antioxidant (AOH) and multifunctional (MFH) hydrogels are the most effective for DFU treatment, with a recommended treatment strategy of using AOH first, followed by antibacterial hydrog