Publications by authors named "Renfa Huang"
Article Synopsis
- Scrub typhus is a serious public health concern, and understanding the specific factors contributing to its occurrence is essential for effective prevention and treatment in the Gannan region.
- The study employed various statistical methods, including spatial autocorrelation and regression modeling, to analyze the incidence of scrub typhus over a 14-year period, identifying key influencing factors like DEM, temperature, and wind speed.
- Findings revealed that environmental factors, especially the normalized difference vegetation index, as well as economic indicators like GDP, significantly affect scrub typhus incidence, with variations noted across different areas within Gannan.
Background: Scrub typhus poses a substantial risk to human life and wellbeing as it is transmitted by vectors. Although the correlation between climate and vector-borne diseases has been investigated, the impact of climate on scrub typhus remains inadequately comprehended. The objective of this study is to investigate the influence of meteorological conditions on the occurrence of scrub typhus in Ganzhou City, Jiangxi Province.
View Article and Find Full Text PDFAcute kidney injury (AKI) is one of the most challenging clinical problems in kidney disease due to serious complications and high mortality rate, which can lead to acute lung injury (ALI) through inflammatory reactions and oxidative stress. Adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has been reported to be involved in the development of renal ischemia-reperfusion through autophagy and it remains unclear whether AMPK/mTOR pathway has an effect on the AKI-induced ALI. In this study, we aimed to investigate the effects of autophagy-related AMPK/mTOR signaling pathway on inflammatory factors and oxidative stress in an AKI-induced ALI model.
View Article and Find Full Text PDFObjective: To investigate protective effect of Cordyceps sinensis (CS) through autophagy-associated adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling pathway in acute kidney injury (AKI)-induced acute lung injury (ALI).
Methods: Forty-eight male Sprague-Dawley rats were divided into 4 groups according to a random number table, including the normal saline (NS)-treated sham group (sham group), NS-treated ischemia reperfusion injury (IRI) group (IRI group), and low- (5 g/kg·d) and high-dose (10 g/kg·d) CS-treated IRI groups (CS1 and CS2 groups), 12 rats in each group. Nephrectomy of the right kidney was performed on the IRI rat model that was subjected to 60 min of left renal pedicle occlusion followed by 12, 24, 48, and 72 h of reperfusion.
Aim: This study aimed to investigate the regulatory role of autophagy in acute kidney injury (AKI) induced acute lung injury (ALI).
Methods: The male Sprague-Dawley rats were divided into four groups: normal saline-treated sham rats (sham group), normal saline-treated ischemia-reperfusion injury rats (IRI group), 3-methyladenine-treated IRI rats (3-MA group), and rapamycin-treated IRI rats (RA group). The rats in the IRI rat model received the nephrectomy of the right kidney and was subjected to 60 mins of left renal pedicle occlusion, followed by 12, 24, 48, and 72 h of reperfusion.
Objective: To investigate the effect of both fermented Cordyceps powder (CS) and prednisone on the Notch2/hes-1 signaling activation in the kidney tubules of rats with acute aristolochic acid nephropathy (AAAN).
Methods: Totally 50 SD rats were randomly divided into 4 groups, i.e.
[Effect of Cordyceps sinensis on the expression of HIF-1α and NGAL in rats with renal ischemia-reperfusion injury].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
January 2012
Objective: To observe the level of urinary neutrophil gelatinase-associated lipocalin (NGAL), the expression of hypoxia inducible factor-1α (HIF-1α) and NGAL in rat kidney after renal ischemia and reperfusion (I/R), before and after the treatment with Cordyceps Sinensis (C. sinensis), and to explore the mechanism of C. sinensis against I/R injury.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores how the Notch signaling pathway contributes to inflammation and cell death (apoptosis) following renal ischemia/reperfusion injury (IRI) in male rats, evaluating both the physiological and biochemical changes.
- - Rats were treated with either normal saline or a Notch inhibitor (DAPT) after undergoing kidney damage, and various markers were assessed, including creatinine levels and protein expressions related to inflammation and apoptosis.
- - Results showed that Notch signaling activation worsened kidney damage, but DAPT treatment significantly improved kidney function and reduced inflammation and cell death, highlighting the potential therapeutic role of inhibiting the Notch pathway in renal IRI cases.