Risk of venous thromboembolism and major bleeding in the clinical course of osteosarcoma and Ewing sarcoma.

Background: Patients with osteosarcoma (OS) and Ewing sarcoma (ES) are considered to have a high venous thromboembolism (VTE) risk, although the exact incidence and prognostic impact are under-researched in general as well as in relevant age groups.

Aims: To study the impact of VTE and major bleeding (MB) in OS and ES patients, subdivided in children, Adolescents Young Adults (AYAs; aged 18-39) and older adults.

Methods: Retrospective single-center chart review in 519 OS and 165 ES patients treated between 1980 and 2018.