Publications by authors named "Renee Tung"
Recent studies in mice have shown that orofacial behaviors drive a large fraction of neural activity across the brain. To understand the nature and function of these signals, we need better computational models to characterize the behaviors and relate them to neural activity. Here we developed Facemap, a framework consisting of a keypoint tracker and a deep neural network encoder for predicting neural activity.
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- - Absence seizures are short episodes where individuals experience impaired consciousness and unresponsiveness, and their underlying neuronal mechanisms are not fully understood, though they are observed in both humans and an awake female rat model.
- - In this model, researchers found that there are decreases in overall neuronal firing during seizures, but patterns of activity among individual neurons vary, including initial surges in firing followed by sustained decreases.
- - Notably, changes in brain activity begin 40-60 seconds prior to a seizure, showing a decline in low-frequency brain waves and behavioral activity, while higher-frequency brain activity and neuronal rhythmicity increase, indicating that significant brain state shifts occur before seizures happen.
Purpose: In a prior bioequivalence study, generic brittle (GB) patients with epilepsy who were considered at risk of worsened seizures or drug side effects from switching antiepileptic drug (AED) formulations demonstrated no significant difference in their drug levels when switched between a brand and generic AED. An alternative basis for being GB may relate to having a personality or mindset that predisposes to poor outcomes from a formulation switch. The objective of this study was to explore whether GB patients with epilepsy could be differentiated from not GB patients based on standardized measures of personality, mood, outlook, and beliefs.
View Article and Find Full Text PDFPurpose: The purpose of this study was to provide an algorithm for generic brittleness and to elucidate the demographic factors that anticipate generic brittleness for patients with epilepsy.
Methods: This exploratory, observational, and nontherapeutic study was conducted in patients with epilepsy who were routinely followed at the University of Maryland epilepsy outpatient clinic in Baltimore, Maryland. Patients were taking at least one antiepileptic drug (AED) for treatment of epilepsy.
Pulse wave velocity (PWV) has been shown to influence the effects of antihypertensive drugs in the prevention of cardiovascular diseases. Data are limited on whether PWV is an independent predictor of stroke above and beyond hypertension control. This longitudinal analysis examined the independent and joint effect of brachial-ankle PWV (baPWV) with hypertension control on the risk of first stroke.
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