Publications by authors named "Renee Procopio-Melino"
Article Synopsis
- Next-generation cysteine-based antibody-drug-conjugates (ADCs) improve therapeutic outcomes by allowing for precise drug attachment to antibodies.
- *The development of a new antibody manufacturing process using cysteine metabolic engineering and a unique capping technology simplifies the production of these ADCs, enhancing their quality.
- *This innovative method could pave the way for combining different site-specific conjugation techniques, potentially leading to the creation of multi-drug ADCs that target cancer more effectively.
Raman-based multivariate calibration models have been developed for real-time in situ monitoring of multiple process parameters within cell culture bioreactors. Developed models are generic, in the sense that they are applicable to various products, media, and cell lines based on Chinese Hamster Ovarian (CHO) host cells, and are scalable to large pilot and manufacturing scales. Several batches using different CHO-based cell lines and corresponding proprietary media and process conditions have been used to generate calibration datasets, and models have been validated using independent datasets from separate batch runs.
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