Fecal blood loss: A quantitative method of evaluating hemostasis in patients with thrombocytopenia.

Background: The purpose of our studies was to determine if fecal blood loss can provide a quantitative measure of bleeding at platelet counts of 20 000/μL or less in patients with hypoproliferative thrombocytopenia and to document the effects of different prophylactic platelet transfusion triggers on fecal blood loss.

Methods And Materials: Patients had an aliquot of their autologous red blood cells (RBCs) labeled with Cr. Following reinjection of their radiolabeled RBCs, all feces and a daily blood sample were collected to determine fecal blood loss per day.

A MULTICENTER, LONGITUDINAL, INTERVENTIONAL, DOUBLE BLIND RANDOMIZED CLINICAL TRIAL IN HEMATOPOIETIC CELL TRANSPLANT RECIPIENTS RESIDING IN REMOTE AREAS: LESSONS LEARNED FROM THE LATE CYTOMEGALOVIRUS PREVENTION TRIAL.

Purpose: The logistics of conducting double-blinded phase III clinical trials with participants residing in remote locations are complex. Here we describe the implementation of an interventional trial for the prevention of late cytomegalovirus (CMV) disease in hematopoietic cell transplantation (HCT) subjects in a long-term follow-up environment.

Methods: A total of 184 subjects at risk for late CMV disease surviving 80 days following allogeneic HCT were randomized to receive six months of valganciclovir or placebo.

A randomized clinical trial of cognitive-behavioral therapy and applied relaxation for adults with generalized anxiety disorder.

This randomized clinical trial compared cognitive-behavioral therapy (CBT), applied relaxation (AR), and wait-list control (WL) in a sample of 65 adults with a primary diagnosis of generalized anxiety disorder (GAD). The CBT condition was based on the intolerance of uncertainty model of GAD, whereas the AR condition was based on general theories of anxiety. Both manualized treatments were administered over 12 weekly 1-hour sessions.

Comparative psychometric properties of the BACS and RBANS in patients with schizophrenia and schizoaffective disorder.

Objectives: There has been a recent impetus to develop short and portable instruments for the cognitive assessment of patients with schizophrenia in clinical settings, but direct comparative data are lacking. The objectives of the present study were to compare the psychometric properties of two such batteries, the BACS (Brief Assessment of Cognition in Schizophrenia) and the RBANS (Repeatable Battery for the Assessment of Neuropsychological Status).

Methods: The French version of the BACS and the RBANS was administered to 36 patients with schizophrenia and schizoaffective disorder, and 14 healthy controls.