Bupropion as a possible treatment option for restless legs syndrome.

Objective: To describe a case of restless legs syndrome (RLS) successfully managed with bupropion.

Case Summary: A 45-year-old female presented to a Veterans Affairs primary care clinic with a history of chronic insomnia. Her complicated history of treatment failure to sedative-hypnotic agents, continued sleep disturbances, and complaints of intolerable leg sensations fostered collaboration between a psychiatrist and pharmacist to identify effective treatment.