Simulated change in body fatness affects Hologic QDR 4500A whole body and central DXA bone measures.

Changes in body fatness may impact the accuracy of dual energy X-ray absorptiometry (DXA) measures of bone mineral content (BMC) and bone mineral density (BMD). The aim of this study was to determine if DXA can accurately assess BMC and BMD with changes in exogenous fat (lard) placed to simulate weight change. Whole body (WB), lumbar spine (LS), and proximal femur (PF) DXA scans (Hologic QDR 4500A) were performed on 30 elderly (52-83 yr) and 60 young (18-40 yr) individuals (i.