Publications by authors named "Rene Paschall"
Article Synopsis
- Cats with chronic kidney disease (CKD) have increased serum uremic toxins that can be harmful.
- The study tested Renaltec, an oral treatment that absorbs these toxins in the gut by using 13 cats with CKD.
- Results showed that both once-daily and twice-daily doses of Renaltec significantly reduced harmful uremic toxins in the blood, with twice-daily dosing proving more effective.
Objectives: The aim of the present study was to assess the effect of gabapentin on blood pressure (BP) in cats with and without chronic kidney disease (CKD).
Methods: A randomized, blinded, placebo-controlled crossover study was performed. A total of 29 cats were included: 13 cats with stable CKD (IRIS stage 2-4) and 16 apparently healthy cats (serum creatinine <1.
Appetite abnormalities and weight loss are important comorbidities in the treatment of chronic kidney disease (CKD) in cats. Ghrelin, a key hormone involved in the regulation of appetite and metabolism, is a potential marker of appetite dysregulation in cats with CKD. The aim of this study was to compare the plasma concentrations of acylated, desacyl, and total ghrelin in normal cats and cats with CKD.
View Article and Find Full Text PDFMeasuring 25-hydroxyvitamin D (25D) can be a challenge in veterinary medicine because of laboratory accessibility and required sample volume. We compared 2 dried-blood-spot (DBS) tests and a lateral flow assay (LFA) to the gold standard, liquid chromatography-tandem mass spectrometry (LC-MS/MS). We hypothesized that there would be good agreement among the tests, within a clinically significant limit of agreement of ± 25 nmol/L.
View Article and Find Full Text PDFBackground: Hypoxia is a key driver of fibrosis and is associated with capillary rarefaction in humans.
Objectives: Characterize capillary rarefaction in cats with chronic kidney disease (CKD).
Animals: Archival kidney tissue from 58 cats with CKD, 20 unaffected cats.
Objectives: The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats.
Methods: Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of gabapentin was administered orally and blood was obtained at 0, 0.
Kidney tissues from cats with naturally occurring chronic kidney disease (CKD) and adult and senior cats without CKD were assessed to determine whether telomere shortening and nitrosative stress are associated with senescence in feline CKD. The histopathologic assessment of percent global glomerulosclerosis, inflammatory infiltrate, and fibrosis was performed. Senescence and nitrosative stress were evaluated utilizing p16 and iNOS immunohistochemistry, respectively.
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