Publications by authors named "Rene Garcia-Del Valle"
Article Synopsis
- The text discusses a specific bacterium found in tropical and subtropical regions that can cause severe illnesses in humans and animals; the focus is on synthesizing new acyl homoserine lactones (HSLs) to evaluate their ability to inhibit bacterial communication (quorum sensing).
- The synthesized HSLs were tested for their effectiveness in reducing the production of specific signaling molecules and biofilms, with the most effective compound being -(2-hexadecynoyl)-l-homoserine lactone, which showed significant activity at various concentrations without being toxic to Vero cells.
- Molecular docking studies further indicate that this compound interacts favorably with the CviR receptor, suggesting that these novel H
The antibacterial activity of fatty acids (FA) is well known in the literature and represents a promising option for developing the next-generation of antibacterial agents to treat a broad spectrum of bacterial infections. FA are highly involved in living organisms' defense system against numerous pathogens, including multidrug-resistant bacteria. When combined with other antibacterial agents, the remarkable ability of FA to enhance their bactericidal properties is a critical feature that is not commonly observed in other naturally-occurring compounds.
View Article and Find Full Text PDF