High Expression Confers Poor Prognosis in Colorectal Cancer, and Represents a Novel Therapeutic Target in BRAF-Mutated Colorectal Cancer.

We aimed to investigate the role of expression in colorectal cancer (CRC) prognosis and evaluate its potential as a therapeutic target in -mutated CRC. : Exactly 136 samples of formalin-fixed paraffin-embedded CRC tissue specimens were obtained from patients who underwent surgical resection for CRC. The gene mutation status of the samples was detected using fluorescence PCR.

Exosomal B7-H3 facilitates colorectal cancer angiogenesis and metastasis through AKT1/mTOR/VEGFA pathway.

B7-H3 (CD276), an immune checkpoint molecule, is aberrantly overexpressed in many types of cancer, and plays important roles in tumor immune evasion, carcinogenesis and metastasis, as well as angiogenesis. However, the mechanisms underlying B7-H3-promoted angiogenesis are still largely unknown. In this study, based on the observation of overexpression of B7-H3 on the tumor cells and vascular endothelial cells (VECs) in colorectal cancer (CRC) tissues, we investigated the roles of cancer cell-drived exosomal B7-H3 in tumor angiogenesis and metastasis through crosstalk between cancer cells and VECs.

Effect of flux components of lightweight aggregate on physical properties and heavy metal solidification performance.

The preparation of lightweight aggregate (LWA) by high-temperature sintering is a promising method for recycling solid waste safely, especially for solidifying heavy metals effectively. The main aim of this research was to systematically evaluate the effects of the flux components on LWA, including NaO, MgO, CaO, and FeO. The physical properties and chromium solidification mechanism of LWA were characterized and analyzed.

Multiple sclerosis and fracture.

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating central nervous system disease with time and space disseminated lesions that usually occurs in young adults, typically aged between 20 and 45 years. Recently, researches have indicated MS may be associated with increased risk of fracture and osteoporosis. In this review, we aim to identify the fracture risk in MS patients, also address the pathogenic mechanisms and interventions of fracture in those patients.

[Change in humoral immunological function and their clinical significance in patients with cerebral hemorrhage].

Objective: To study the changes in humoral immunological function and their clinical significance in cerebral hemorrhage.

Methods: Among 115 cases of cerebral hemorrhage, there was low volume bleeding in 39 case, middle volume in 37 cases, and large volume in 39 cases. The ratios of CD19+-CD25+ and CD19+-CD25-B lymphocytes were determined by flow cytometry, and the content of IgA, IgG, IgM, and complement C3 were determined with scattered turbidimetry.