KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma.

Brusatol (Bru), a main extract from traditional Chinese medicine Brucea javanica, has been reported to exist antitumor effect in many tumors including melanoma. However, the underlying mechanism in its anti-melanoma effect still need further exploration. Here, we reported that the protein expression of KLF4 in melanoma cells were significantly downregulated in response to brusatol treatment.

Two Cases of Treatment of Moderate to Severe Acne with an Acupuncture-Debridement Microsurgical Technique and Review of the Literature.

Acne is a chronic inflammatory disease of pilosebaceous glands. Microsurgical acupuncture and debridement technique is one of the most precise and effective external treatment for acne. We introduce successful treatment of two cases of moderate to severe acne with this technique and describe the characteristics and mechanism of the technique in detail.