Publications by authors named "Renaud Schoemans"
Article Synopsis
- PKU is a genetic disorder caused by low activity of the phenylalanine hydroxylase enzyme, which can lead to brain hypomyelination if untreated.
- Research using a PKU mouse model showed that the number of oligodendrocytes in the brain is similar to control mice, indicating no direct loss of these cells.
- Experiments revealed that high levels of phenylalanine and its byproducts do not have a toxic effect on oligodendrocytes or disrupt the myelination process, suggesting that the cause of brain hypomyelination in PKU may involve other factors apart from elevated phenylalanine.
Mesenchymal stem cells (MSCs) are studied as a cellular source for the treatment of various diseases. In this work, we isolated and cultivated murine bone marrow-derived MSCs. After a first observation of a solid tumor in a mouse injected with these cells, we systematically explored their chromosomal stability.
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