Publications by authors named "Renaud Guignard"
Background: We assessed and compared image quality obtained with clinical F-FDG whole-body oncologic PET protocols used in three different, state-of-the-art digital PET/CT and two conventional PMT-based PET/CT devices. Our goal was to evaluate an improved trade-off between administered activity (patient dose exposure/signal-to-noise ratio) and acquisition time (patient comfort) while preserving diagnostic information achievable with the recently introduced digital detector technology compared to previous analogue PET technology.
Methods: We performed list-mode (LM) PET acquisitions using a NEMA/IEC NU2 phantom, with activity concentrations of 5 kBq/mL and 25 kBq/mL for the background (9.
Background: Neuropsychiatric symptoms, also known as behavioral and psychological symptoms of dementia (BPSD), affect the majority of patients with dementia, and result in a greater cognitive and functional impairment.
Objective: To investigate associations between BPSD and amyloid cerebral deposition as measured by 18F-Florbetapir-PET quantitative uptake in elderly subjects with and without cognitive impairment.
Methods: Participants with cognitive impairment [mild cognitive impairment (MCI) or Alzheimer's disease (AD)] and healthy controls (HC) from the ADNI cohort (Alzheimer Disease Neuroimaging Initiative) who underwent an 18F-florbetapir PET scan between May 2010 and March 2014 were included.
The study of peripheral nerves (PN) is a challenge because of the orientation, size, and also because of the fact that these pathologies are not well known. The diagnosis of PN damage was based exclusively on clinical examination and electrophysiologic testing until few years ago. MRI is the examination of choice for studying peripheral nerves; recently, magnetic resonance neurography has been added as a part of clinical routine.
View Article and Find Full Text PDFPurpose: We tested the performance and clinical applicability of combined protocols for brain imaging studies acquired on a new whole-body hybrid PET/MR scanner.
Patients And Methods: Fifteen patients [6 male and 9 female patients; mean (SD) age, 51 (30) y; range, 6-89 y] were scanned on a Philips Ingenuity TF PET/MR. Standard imaging protocols of both modalities were combined, using a "head coil" and contrast-enhanced fully diagnostic MR protocols.
Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D(2) receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased.
View Article and Find Full Text PDFPurpose: Effective management of patients affected by retroperitoneal fibrosis (RPF) is an important issue because of lack of relevant parameters to objectively assess the degree of inflammation. We evaluated added value of contrast-enhanced computed tomography (CE-CT) combined with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) as a one-stop diagnostic procedure for the assessment and follow-up of patients with RPF.
Materials And Methods: (18)F-FDG PET and CE-CT findings were reviewed in 10 patients suffering from RPF.
Objective: Delayed graft function is a frequent complication after kidney transplantation impacting aversely on graft survival. The aim of this study was to assess the prognostic value of quantitative scintigraphic parameters immediately after transplantation in this population.
Methods: One hundred patients with renal transplants suffering from delayed graft function were included in this study.