Publications by authors named "Renaud Grima"

Article Synopsis
  • The Lungsco01 study is the first to evaluate the effectiveness and economic impact of video-thoracoscopy compared to open thoracotomy for treating non-small cell lung cancer in France, involving 259 patients from 10 medical centers over a four-year period.
  • Results indicated that the average costs for open thoracotomy were lower than for video-thoracoscopy at both 30 days and 3 months post-surgery, with video-thoracoscopy showing a higher incremental cost-utility ratio per additional quality-adjusted life-year (QALY) gained.
  • The analysis revealed a 64% probability that video-thoracoscopy was cost-effective at the 30-day mark
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Background: Surgical rib fixation for multiple rib fractures and flail chest has become more common in the 2000s with interesting results in selected patients. However, surgical rib fixation lacks a consensus on the delay to surgery and the benefits on postoperative clinical outcomes. Our goal was to determine if delay to surgery can affect postoperative outcomes.

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Article Synopsis
  • A study on Stage IVa thymoma, a rare cancer, evaluated the effects of subtotal pleurectomy and HITHOC treatment on patients with either de novo tumors or distant relapses.
  • The research analyzed 40 patients over 24 years, finding a hospital mortality rate of 2.5% and significant differences in disease-free intervals between de novo tumors (49 months) and distant relapses (85 months).
  • The study concludes that HITHOC combined with pleurectomy may yield favorable outcomes for selected patients, but more multicentric research is necessary to establish it as a standard treatment.
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Article Synopsis
  • Lung cancer screening often leads to the discovery of small pulmonary nodules that may require surgery to determine if they are cancerous; the study investigated the effectiveness of video-assisted thoracoscopic surgery (VATS) in these cases.* -
  • A comprehensive analysis of 651 patients who had surgery for suspicious pulmonary nodules revealed that those who underwent VATS had significantly more wedge resections, while thoracotomy patients were more frequently diagnosed with lung cancer.* -
  • Although VATS resulted in a higher rate of surgical procedures for benign lesions, the overall occurrence of lobectomies for benign conditions was not significantly different compared to traditional thoracotomy techniques.*
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For patients with locally advanced non-small cell lung cancer invading the spine, induction chemoradiotherapy combined with radical en bloc resection is the key to obtaining long-term survival. With time, our operative technique evolved to a two-step surgery as we experienced numerous perioperative complications during one step surgery. The aim of our study was to assess postoperative morbimortality and long-term survival of both techniques.

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Background: Video-assisted surgical lung biopsy (SLB) is performed in 10-30% of cases to establish the diagnosis of idiopathic pulmonary fibrosis (IPF).

Objectives: The aim of the study was to analyze the impact of SLB on lung function in patients eventually diagnosed with IPF.

Methods: This is an observational, retrospective, monocentric study of all consecutive patients eventually diagnosed with IPF in multidisciplinary discussion who underwent SLB over 10 years in a specialized center.

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Background: After lung transplantation (LT), between 2% and 25% of bronchial anastomoses develop complications requiring therapeutic intervention. The status of healing of both bronchial anastomoses and downhill airways are well described by the French consensual MDS standardized grading system (Macroscopic, Diameter, Suture). We analyzed risks factors for airway complications (AC) after transplantation and the way we managed them.

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Objectives: Solid organ transplantation is an accepted treatment for end-stage organ failure. Long-lasting immunosuppressive therapy may increase the risk ofde novo malignancies in transplant recipients. Increased risk of bronchogenic carcinoma in this population is controversial but prolonged transplant recipients' survival (obtained in modern transplantation era) may increase the need for lung cancer surgical resection in immunosuppressed patients.

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Several surgical procedures, from debulking to extrapleural pneumonectomy, may be applied for stage IVa Masaoka thymomas, but their efficiency is still controversial. Case studies have favored R resection as the cornerstone of multimodal therapy for locoregional metastatic extension. This report describes a standardized procedure combining a cytoreductive surgical procedure and intrathoracic chemohyperthermia on a 46-year-old patient presenting with B2 thymoma and synchronous unilateral pleural metastasis.

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Background: Pleural recurrences are a hallmark of thymomas, and represent a challenge for multidisciplinary management. The purpose of this study was to assess the feasibility and the results in terms of morbidity, mortality and survival rates, of Intra-Thoracic Chemo-Hyperthermia (ITCH) for the treatment of pleural recurrences of thymomas.

Methods: Retrospective analysis of 19 consecutives patients between 1997 and 2015 treated by surgical cytoreduction (pleurectomy) followed by ITCH with 25mg/m of mitomycin, and 50mg/m of Cisplatin.

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Objectives: Thoracoplasty has lost much of its popularity and is being supplanted by space-reduction operations using muscle flaps. Our purpose is to retrospectively study the remaining indications and the evolving modifications of this ancient technique in our current surgical practice.

Patients And Methods: From 1994 to 2008, 35 patients underwent a thoracoplasty procedure in a single thoracic surgery centre for treatment of infectious complications of previous thoracic surgery.

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Objective: Lung resection for complex aspergilloma (CA) carries high morbidity and mortality and remains controversial in high-risk patients. Cavernostomy followed by muscle-flap plombage has been recommended for patients considered unfit for resection, but subsequent muscle-flap atrophy may be a main cause of failure. We reviewed the place of a limited thoracoplasty in association with that procedure.

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