Publications by authors named "Renaud Binette"
Article Synopsis
- Bovine mastitis is a significant infection caused by a pathogen that also affects humans, making antibiotic resistance a critical issue across both species.
- The need for new antibiotics considers the One Health concept, which focuses on the interconnectedness of human, animal, and environmental health.
- PC206, a novel antibiotic with improved stability, has shown effectiveness against the pathogen causing mastitis and is well tolerated in both mice and cows, offering a promising solution for treatment in dairy farms.
In order to modify amino acids, the C-terminus carboxylic acid usually needs to be protected, typically as a methyl ester. However, standard cleavage of methyl esters requires either highly basic or acidic conditions, which are not compatible with Fmoc or acid-labile protecting groups. This highlights the need for orthogonal conditions that permit selective deprotection of esters to create SPPS-ready amino acids.
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