Intra-articular ozone slows down the process of degeneration of articular cartilage in the knees of rats with osteoarthritis.

Background: Osteoarthritis (OA) is a joint disease of multifactorial etiology, affecting mainly the knees. We aimed to evaluate the effects of two different doses of gaseous ozone intra-articularly on the knee cartilage morphology of rats with osteoarthritis (OA).

Methods: The articular lesion was induced by sodium monoiodoacetate (MIA).