Publications by authors named "Renato Margeta"
Article Synopsis
- The research focused on creating radiotracers that specifically target bacterial infections by utilizing the unique iron transport system known as siderophores.
- The synthesis and radiolabeling process produced a radiotracer called [Ga]Ga-RMA693, derived from salmochelin.
- In tests with an animal model of infection, this radiotracer demonstrated a favorable distribution in the body and targeted uptake in the presence of bacteria.
Ibrutinib is an inhibitor of Bruton's tyrosine kinase that has been approved for the treatment of patients with chronic lymphocytic leukemia, mantle cell lymphoma and Waldenstrom's macroglobulinemia and is connected with toxicities. To minimize its toxicities, we linked ibrutinib to a cell-targeted, internalizing antibody. To this end, we synthesized a poly-anionic derivate, ibrutinib-Cy3.
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